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Cenpn centromere protein N [ Rattus norvegicus (Norway rat) ]

Gene ID: 361416, updated on 27-Nov-2024

Summary

Official Symbol
Cenpnprovided by RGD
Official Full Name
centromere protein Nprovided by RGD
Primary source
RGD:1310953
See related
EnsemblRapid:ENSRNOG00000011296 AllianceGenome:RGD:1310953
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Da2-4; Da2-27; RGD1310953
Summary
Predicted to be involved in CENP-A containing chromatin assembly and chromosome segregation. Predicted to be located in chromosome, centromeric region and nucleus. Predicted to be part of inner kinetochore. Predicted to be active in nucleoplasm. Orthologous to human CENPN (centromere protein N). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 98.0), Thymus (RPKM 68.3) and 9 other tissues See more
Orthologs
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Genomic context

See Cenpn in Genome Data Viewer
Location:
19q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (61880101..61902850)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (44971265..44994019)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (49457461..49479989)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene dynein light chain roadblock-type 2 Neighboring gene chromodomain Y-like 2 Neighboring gene uncharacterized LOC134483651 Neighboring gene C-x(9)-C motif containing 2 Neighboring gene similar to human chromosome 16 open reading frame 46 Neighboring gene ATM interactor

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC94524

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
centromere protein N
Names
CENP-N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008366.1NP_001008367.1  centromere protein N

    See identical proteins and their annotated locations for NP_001008367.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085839
    UniProtKB/Swiss-Prot
    Q5U2W4
    UniProtKB/TrEMBL
    A0A0H2UHI9, A6IZF9
    Conserved Domains (1) summary
    pfam05238
    Location:4340
    CENP-N; Kinetochore protein CHL4 like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    61880101..61902850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097868.2XP_038953796.1  centromere protein N isoform X1

    UniProtKB/Swiss-Prot
    Q5U2W4
    UniProtKB/TrEMBL
    A0A0H2UHI9, A6IZF9
    Related
    ENSRNOP00000015158.6, ENSRNOT00000015158.8
    Conserved Domains (1) summary
    pfam05238
    Location:4340
    CENP-N; Kinetochore protein CHL4 like
  2. XM_063278143.1XP_063134213.1  centromere protein N isoform X2

    UniProtKB/TrEMBL
    A0A8L2UQ64
    Related
    ENSRNOP00000071328.3, ENSRNOT00000084445.3
  3. XM_006255687.5XP_006255749.1  centromere protein N isoform X1

    See identical proteins and their annotated locations for XP_006255749.1

    UniProtKB/Swiss-Prot
    Q5U2W4
    UniProtKB/TrEMBL
    A0A0H2UHI9, A6IZF9
    Conserved Domains (1) summary
    pfam05238
    Location:4340
    CENP-N; Kinetochore protein CHL4 like
  4. XM_039097869.2XP_038953797.1  centromere protein N isoform X1

    UniProtKB/Swiss-Prot
    Q5U2W4
    UniProtKB/TrEMBL
    A0A0H2UHI9, A6IZF9
    Conserved Domains (1) summary
    pfam05238
    Location:4340
    CENP-N; Kinetochore protein CHL4 like
  5. XM_006255692.5XP_006255754.1  centromere protein N isoform X2

    See identical proteins and their annotated locations for XP_006255754.1

    UniProtKB/TrEMBL
    A0A0H2UHI9, A0A8L2UQ64
    Conserved Domains (1) summary
    pfam05238
    Location:3320
    CENP-N; Kinetochore protein CHL4 like
  6. XM_006255689.5XP_006255751.1  centromere protein N isoform X1

    See identical proteins and their annotated locations for XP_006255751.1

    UniProtKB/Swiss-Prot
    Q5U2W4
    UniProtKB/TrEMBL
    A0A0H2UHI9, A6IZF9
    Conserved Domains (1) summary
    pfam05238
    Location:4340
    CENP-N; Kinetochore protein CHL4 like
  7. XM_006255686.5XP_006255748.1  centromere protein N isoform X1

    See identical proteins and their annotated locations for XP_006255748.1

    UniProtKB/Swiss-Prot
    Q5U2W4
    UniProtKB/TrEMBL
    A0A0H2UHI9, A6IZF9
    Conserved Domains (1) summary
    pfam05238
    Location:4340
    CENP-N; Kinetochore protein CHL4 like
  8. XM_006255691.5XP_006255753.1  centromere protein N isoform X2

    See identical proteins and their annotated locations for XP_006255753.1

    UniProtKB/TrEMBL
    A0A0H2UHI9, A0A8L2UQ64
    Conserved Domains (1) summary
    pfam05238
    Location:3320
    CENP-N; Kinetochore protein CHL4 like
  9. XM_039097870.2XP_038953798.1  centromere protein N isoform X1

    UniProtKB/Swiss-Prot
    Q5U2W4
    UniProtKB/TrEMBL
    A0A0H2UHI9, A6IZF9
    Conserved Domains (1) summary
    pfam05238
    Location:4340
    CENP-N; Kinetochore protein CHL4 like