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Cdk10 cyclin-dependent kinase 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361434, updated on 27-Nov-2024

Summary

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Official Symbol
Cdk10provided by RGD
Official Full Name
cyclin-dependent kinase 10provided by RGD
Primary source
RGD:1304851
See related
EnsemblRapid:ENSRNOG00000016088 AllianceGenome:RGD:1304851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in Kidney (RPKM 137.7), Adrenal (RPKM 136.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdk10 in Genome Data Viewer
Location:
19q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68168040..68184923)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51260012..51273009)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56024903..56032610)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 1A Neighboring gene spermatogenesis associated 33 Neighboring gene spermatogenesis associated 2-like Neighboring gene VPS9 domain containing 1 Neighboring gene zinc finger protein (C2H2 type) 276 Neighboring gene FA complementation group A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human CDK10 gene isoforms. Sergère JC, et al. Biochem Biophys Res Commun, 2000 Sep 16. PMID 11006117
  2. STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis. Guen VJ, et al. Cell Cycle, 2016. PMID 27104747, Free PMC Article
  3. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Guen VJ, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218572, Free PMC Article
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112847

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 10
Names
cell division protein kinase 10
cyclin-dependent kinase (CDC2-like) 10
NP_001020893.2
NP_001103406.1
NP_001103407.1
XP_038953809.1
XP_038953810.1
XP_038953811.1
XP_038953813.1
XP_038953814.1
XP_063134227.1
XP_063134228.1
XP_063134229.1
XP_063134230.1
XP_063134231.1
XP_063134232.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025722.2 → NP_001020893.2  cyclin-dependent kinase 10 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This minor variant (3) contains an alternate 5' end exon compared to transcript variant 1, and encodes a longer isoform (3) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI071224, BC098804
    UniProtKB/Swiss-Prot
    Q4KM47
    UniProtKB/TrEMBL
    F1LSV8
    Related
    ENSRNOP00000059465.1, ENSRNOT00000066552.5
    Conserved Domains (1) summary
    cd07845
    Location:41 → 349
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

  2. NM_001109936.1 → NP_001103406.1  cyclin-dependent kinase 10 isoform 1

    See identical proteins and their annotated locations for NP_001103406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the most predominant transcript and encodes isoform 1.
    Source sequence(s)
    AI071224, BC098804, DN935585, DY320517
    UniProtKB/TrEMBL
    A6IZW7, A6IZW8, G3V814
    Conserved Domains (1) summary
    cd07845
    Location:31 → 339
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

  3. NM_001109937.1 → NP_001103407.1  cyclin-dependent kinase 10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different donor splice site at the first exon compared to transcript variant 1, resulting in translation initiation from an in-frame, downstream AUG, and a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AI071224, BC098804, DN932869
    UniProtKB/Swiss-Prot
    Q4KM47
    Conserved Domains (1) summary
    cd07845
    Location:1 → 268
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    68168040..68184923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278161.1 → XP_063134231.1  cyclin-dependent kinase 10 isoform X7

  2. XM_063278158.1 → XP_063134228.1  cyclin-dependent kinase 10 isoform X5

  3. XM_063278160.1 → XP_063134230.1  cyclin-dependent kinase 10 isoform X6

  4. XM_039097882.2 → XP_038953810.1  cyclin-dependent kinase 10 isoform X2

    UniProtKB/TrEMBL
    A6IZW7
    Related
    ENSRNOP00000021607.5, ENSRNOT00000021607.10
    Conserved Domains (1) summary
    cd07845
    Location:31 → 374
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

  5. XM_039097885.2 → XP_038953813.1  cyclin-dependent kinase 10 isoform X5

    UniProtKB/Swiss-Prot
    Q4KM47
    Conserved Domains (1) summary
    cd07845
    Location:1 → 303
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

  6. XM_039097881.2 → XP_038953809.1  cyclin-dependent kinase 10 isoform X1

    UniProtKB/Swiss-Prot
    Q4KM47
    Conserved Domains (1) summary
    cd07845
    Location:41 → 384
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

  7. XM_063278159.1 → XP_063134229.1  cyclin-dependent kinase 10 isoform X5

  8. XM_039097883.2 → XP_038953811.1  cyclin-dependent kinase 10 isoform X3

    UniProtKB/Swiss-Prot
    Q4KM47
    Conserved Domains (1) summary
    cd07845
    Location:41 → 373
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

  9. XM_063278157.1 → XP_063134227.1  cyclin-dependent kinase 10 isoform X4

  10. XM_039097886.2 → XP_038953814.1  cyclin-dependent kinase 10 isoform X5

    UniProtKB/Swiss-Prot
    Q4KM47
    Conserved Domains (1) summary
    cd07845
    Location:1 → 303
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

  11. XM_063278162.1 → XP_063134232.1  cyclin-dependent kinase 10 isoform X8

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KM47.1 GenPept UniProtKB/Swiss-Prot:Q4KM47

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