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Fanca FA complementation group A [ Rattus norvegicus (Norway rat) ]

Gene ID: 361435, updated on 27-Nov-2024

Summary

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Symbol
Fancaprovided by RGD
Full Name
FA complementation group Aprovided by RGD
Primary source
RGD:1311380
See related
EnsemblRapid:ENSRNOG00000016706 AllianceGenome:RGD:1311380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in regulation of regulatory T cell differentiation. Predicted to act upstream of or within several processes, including gonad development; regulation of CD40 signaling pathway; and regulation of germ cell proliferation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); acute myeloid leukemia; esophagus squamous cell carcinoma; ovarian disease (multiple); and skin melanoma. Orthologous to human FANCA (FA complementation group A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 37.1), Spleen (RPKM 27.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fanca in Genome Data Viewer
Location:
19q12
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68210562..68271080, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51304126..51362586, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56067548..56126075, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 10 Neighboring gene spermatogenesis associated 2-like Neighboring gene VPS9 domain containing 1 Neighboring gene zinc finger protein (C2H2 type) 276 Neighboring gene small nucleolar RNA SNORD43 Neighboring gene spire-type actin nucleation factor 2 Neighboring gene transcription factor 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Fanconi anemia in Tunisia: high prevalence of group A and identification of new FANCA mutations. Bouchlaka C, et al. J Hum Genet, 2003. PMID 12827451
  2. Identification and characterization of novel mutations of the major Fanconi anemia gene FANCA in the Japanese population. Yagasaki H, et al. Hum Mutat, 2004 Dec. PMID 15523645
  3. Polymorphisms within the FANCA gene associate with premature ovarian failure in Korean women. Pyun JA, et al. Menopause, 2014 May. PMID 24045675
  4. Polymorphic variations in the FANCA gene in high-risk non-BRCA1/2 breast cancer individuals from the French Canadian population. Litim N, et al. Mol Oncol, 2013 Feb. PMID 23021409, Free PMC Article
  5. Mice with a targeted disruption of the Fanconi anemia homolog Fanca. Cheng NC, et al. Hum Mol Genet, 2000 Jul 22. PMID 10915769

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within female gonad development ISO
Inferred from Sequence Orthology
more info
  
involved_in interstrand cross-link repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within male gonad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of CD40 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of germ cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of regulatory T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Fanconi anaemia nuclear complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Fanconi anaemia nuclear complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Fanconi anemia group A protein
Names
Fanconi anemia group A protein homolog
Fanconi anemia, complementation group A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401252.1 → NP_001388181.1  Fanconi anemia group A protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    Related
    ENSRNOP00000092075.2, ENSRNOT00000107501.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    68210562..68271080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097889.2 → XP_038953817.1  Fanconi anemia group A protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6AGX8
    Conserved Domains (2) summary
    pfam03511
    Location:1096 → 1158
    Fanconi_A; Fanconi anaemia group A protein
    pfam15865
    Location:17 → 365
    Fanconi_A_N; Fanconi anaemia group A protein N-terminus

  2. XM_063278163.1 → XP_063134233.1  Fanconi anemia group A protein isoform X4

  3. XM_039097888.2 → XP_038953816.1  Fanconi anemia group A protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6AGX8
    Related
    ENSRNOP00000105081.1, ENSRNOT00000134755.1
    Conserved Domains (2) summary
    pfam03511
    Location:1252 → 1314
    Fanconi_A; Fanconi anaemia group A protein
    pfam15865
    Location:173 → 521
    Fanconi_A_N; Fanconi anaemia group A protein N-terminus

  4. XM_039097892.2 → XP_038953820.1  Fanconi anemia group A protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6AGX8
    Conserved Domains (1) summary
    pfam15865
    Location:173 → 521
    Fanconi_A_N; Fanconi anaemia group A protein N-terminus

RNA

  1. XR_005496676.2 RNA Sequence

  2. XR_010060017.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108455.1: Suppressed sequence

    Description
    NM_001108455.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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