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Clvs2 clavesin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361459, updated on 4-Jan-2025

Summary

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Official Symbol
Clvs2provided by RGD
Official Full Name
clavesin 2provided by RGD
Primary source
RGD:1306801
See related
AllianceGenome:RGD:1306801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rlbp1l2; Clavesin-2; RGD1306801
Summary
Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity. Involved in lysosome organization. Located in clathrin-coated vesicle and trans-Golgi network. Orthologous to human CLVS2 (clavesin 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 91.5) See more
Orthologs
human mouse all
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Genomic context

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See Clvs2 in Genome Data Viewer
Location:
1p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (25553981..25661806)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (23735660..23842685)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (25173089..25217625)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546868 Neighboring gene ferritin heavy chain 1, pseudogene 4 Neighboring gene solute carrier family 2, facilitated glucose transporter member 3 pseudogene Neighboring gene zinc finger, BED-type containing 4, pseudogene 1 Neighboring gene triadin Neighboring gene succinate dehydrogenase assembly factor 3, mitochondrial-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The clavesin family, neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology. Katoh Y, et al. J Biol Chem, 2009 Oct 2. PMID 19651769, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lysosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
clavesin-2
Names
Retinaldehyde-binding protein 1-like protein 2
retinaldehyde-binding protein 1-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410322.1 → NP_001397251.1  clavesin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    A6JUQ6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    25553981..25661806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266042.1 → XP_063122112.1  clavesin-2 isoform X1

    UniProtKB/Swiss-Prot
    A6JUQ6

  2. XM_063266043.1 → XP_063122113.1  clavesin-2 isoform X1

    UniProtKB/Swiss-Prot
    A6JUQ6

  3. XM_063266047.1 → XP_063122117.1  clavesin-2 isoform X2

    UniProtKB/TrEMBL
    A6JUQ8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108459.1: Suppressed sequence

    Description
    NM_001108459.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6JUQ6.1 GenPept UniProtKB/Swiss-Prot:A6JUQ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials