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cag cag [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36157, updated on 9-Dec-2024

Summary

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Official Symbol
cagprovided by FlyBase
Official Full Name
cagprovided by FlyBase
Primary source
FLYBASE:FBgn0017414
Locus tag
Dmel_CG12346
See related
AllianceGenome:FB:FBgn0017414
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12346; Dmel\CG12346
Summary
Predicted to enable DNA binding activity. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in inner ear disease and primary biliary cholangitis. Orthologous to human CENPB (centromere protein B); TIGD4 (tigger transposable element derived 4); and TIGD6 (tigger transposable element derived 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See cag in Genome Data Viewer
Location:
47C5-47C6; 2-63 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10893034..10894414, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6780539..6781919, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Hydroxyacid oxidase Neighboring gene uncharacterized protein Neighboring gene mir-1008 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B14 subunit Neighboring gene RNA polymerase II, I and III subunit E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pogo-like transposases have been repeatedly domesticated into CENP-B-related proteins. Mateo L, et al. Genome Biol Evol, 2014 Jul 24. PMID 25062917, Free PMC Article
  2. The bHLH transcription factor hand is required for proper wing heart formation in Drosophila. Tögel M, et al. Dev Biol, 2013 Sep 15. PMID 23747982
  3. Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model. Llamusi B, et al. Dis Model Mech, 2013 Jan. PMID 23118342, Free PMC Article
  4. Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. Juneja P, et al. BMC Genomics, 2016 Nov 28. PMID 27894253, Free PMC Article
  5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cag
Names
CG12346-PA
CG12346-PB
cag-PA
cag-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10893034..10894414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057859.4 → NP_477207.1  cag, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477207.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91673, Q7JR24
    Related
    FBpp0087334
    Conserved Domains (2) summary
    smart00674
    Location:78 → 141
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    pfam04218
    Location:7 → 60
    CENP-B_N; CENP-B N-terminal DNA-binding domain

  2. NM_001273947.1 → NP_001260876.1  cag, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260876.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91673, Q7JR24
    Conserved Domains (2) summary
    smart00674
    Location:78 → 141
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    pfam04218
    Location:7 → 60
    CENP-B_N; CENP-B N-terminal DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91673 P91673
Q7JR24 Q7JR24

Gene LinkOut

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