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Emsy EMSY transcriptional repressor, BRCA2 interacting [ Rattus norvegicus (Norway rat) ]

Gene ID: 361607, updated on 27-Nov-2024

Summary

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Official Symbol
Emsyprovided by RGD
Official Full Name
EMSY transcriptional repressor, BRCA2 interactingprovided by RGD
Primary source
RGD:1310712
See related
EnsemblRapid:ENSRNOG00000015560 AllianceGenome:RGD:1310712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310712
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleoplasm. Orthologous to human EMSY (EMSY transcriptional repressor, BRCA2 interacting). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 61.6), Heart (RPKM 56.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Emsy in Genome Data Viewer
Location:
1q32
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (162295167..162364742, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (152881485..152960420, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (163541071..163618576, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C, pseudogene 2 Neighboring gene uncharacterized LOC134484908 Neighboring gene uncharacterized LOC134483759 Neighboring gene THAP domain containing 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69. Ekblad CM, et al. EMBO Rep, 2005 Jul. PMID 15947784, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BRCA2-interacting transcriptional repressor EMSY
Names
EMSY BRCA2-interacting transcriptional repressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400843.1 → NP_001387772.1  BRCA2-interacting transcriptional repressor EMSY

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ATJ6
    Related
    ENSRNOP00000079335.2, ENSRNOT00000120187.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    162295167..162364742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267144.1 → XP_063123214.1  BRCA2-interacting transcriptional repressor EMSY isoform X29

  2. XM_063267115.1 → XP_063123185.1  BRCA2-interacting transcriptional repressor EMSY isoform X21

  3. XM_039101098.2 → XP_038957026.1  BRCA2-interacting transcriptional repressor EMSY isoform X34

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (2) summary
    pfam03735
    Location:19 → 59
    ENT; ENT domain
    NF033645
    Location:934 → 1081
    pilus_FilE; putative pilus assembly protein FilE

  4. XM_039101095.2 → XP_038957023.1  BRCA2-interacting transcriptional repressor EMSY isoform X13

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (2) summary
    pfam03735
    Location:19 → 59
    ENT; ENT domain
    NF033645
    Location:948 → 1095
    pilus_FilE; putative pilus assembly protein FilE

  5. XM_017590189.3 → XP_017445678.1  BRCA2-interacting transcriptional repressor EMSY isoform X6

    UniProtKB/TrEMBL
    D4AC97
    Related
    ENSRNOP00000040421.6, ENSRNOT00000043788.8

  6. XM_063267148.1 → XP_063123218.1  BRCA2-interacting transcriptional repressor EMSY isoform X31

  7. XM_063267141.1 → XP_063123211.1  BRCA2-interacting transcriptional repressor EMSY isoform X28

  8. XM_063267113.1 → XP_063123183.1  BRCA2-interacting transcriptional repressor EMSY isoform X19

  9. XM_063267137.1 → XP_063123207.1  BRCA2-interacting transcriptional repressor EMSY isoform X27

  10. XM_039101099.2 → XP_038957027.1  BRCA2-interacting transcriptional repressor EMSY isoform X25

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (2) summary
    PRK03427
    Location:955 → 1068
    PRK03427; cell division protein ZipA; Provisional
    pfam03735
    Location:19 → 85
    ENT; ENT domain

  11. XM_039101097.2 → XP_038957025.1  BRCA2-interacting transcriptional repressor EMSY isoform X12

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (2) summary
    pfam03735
    Location:19 → 85
    ENT; ENT domain
    NF033645
    Location:959 → 1106
    pilus_FilE; putative pilus assembly protein FilE

  12. XM_063267128.1 → XP_063123198.1  BRCA2-interacting transcriptional repressor EMSY isoform X24

  13. XM_039101094.2 → XP_038957022.1  BRCA2-interacting transcriptional repressor EMSY isoform X10

    UniProtKB/TrEMBL
    A0A8I5YCB7, D4AC97
    Conserved Domains (2) summary
    pfam03735
    Location:19 → 85
    ENT; ENT domain
    NF033645
    Location:973 → 1120
    pilus_FilE; putative pilus assembly protein FilE

  14. XM_039101092.2 → XP_038957020.1  BRCA2-interacting transcriptional repressor EMSY isoform X5

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (2) summary
    pfam03735
    Location:19 → 85
    ENT; ENT domain
    NF033645
    Location:1023 → 1170
    pilus_FilE; putative pilus assembly protein FilE

  15. XM_006229805.5 → XP_006229867.1  BRCA2-interacting transcriptional repressor EMSY isoform X4

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 85
    ENT; ENT domain

  16. XM_063267146.1 → XP_063123216.1  BRCA2-interacting transcriptional repressor EMSY isoform X30

  17. XM_063267093.1 → XP_063123163.1  BRCA2-interacting transcriptional repressor EMSY isoform X14

    Related
    ENSRNOP00000082935.2, ENSRNOT00000098402.2

  18. XM_063267101.1 → XP_063123171.1  BRCA2-interacting transcriptional repressor EMSY isoform X17

    UniProtKB/TrEMBL
    A0A8I5ZN84

  19. XM_063267121.1 → XP_063123191.1  BRCA2-interacting transcriptional repressor EMSY isoform X23

  20. XM_006229808.5 → XP_006229870.1  BRCA2-interacting transcriptional repressor EMSY isoform X8

    UniProtKB/TrEMBL
    A0A8I6AMY7, D4AC97
    Related
    ENSRNOP00000094017.1, ENSRNOT00000117742.2
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  21. XM_039101091.2 → XP_038957019.1  BRCA2-interacting transcriptional repressor EMSY isoform X2

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (2) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain
    NF033645
    Location:1037 → 1184
    pilus_FilE; putative pilus assembly protein FilE

  22. XM_063267084.1 → XP_063123154.1  BRCA2-interacting transcriptional repressor EMSY isoform X9

  23. XM_063267114.1 → XP_063123184.1  BRCA2-interacting transcriptional repressor EMSY isoform X20

  24. XM_006229807.5 → XP_006229869.1  BRCA2-interacting transcriptional repressor EMSY isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZY83
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  25. XM_063267133.1 → XP_063123203.1  BRCA2-interacting transcriptional repressor EMSY isoform X26

  26. XM_006229810.5 → XP_006229872.1  BRCA2-interacting transcriptional repressor EMSY isoform X15

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  27. XM_006229809.5 → XP_006229871.1  BRCA2-interacting transcriptional repressor EMSY isoform X11

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  28. XM_039101096.2 → XP_038957024.1  BRCA2-interacting transcriptional repressor EMSY isoform X18

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (2) summary
    PRK03427
    Location:1020 → 1133
    PRK03427; cell division protein ZipA; Provisional
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  29. XM_006229804.5 → XP_006229866.1  BRCA2-interacting transcriptional repressor EMSY isoform X3

    UniProtKB/TrEMBL
    D4AC97
    Related
    ENSRNOP00000097921.2, ENSRNOT00000112537.2
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  30. XM_006229811.5 → XP_006229873.1  BRCA2-interacting transcriptional repressor EMSY isoform X16

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  31. XM_006229802.5 → XP_006229864.1  BRCA2-interacting transcriptional repressor EMSY isoform X1

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  32. XM_063267155.1 → XP_063123225.1  BRCA2-interacting transcriptional repressor EMSY isoform X32

  33. XM_063267156.1 → XP_063123226.1  BRCA2-interacting transcriptional repressor EMSY isoform X33

  34. XM_006229812.5 → XP_006229874.1  BRCA2-interacting transcriptional repressor EMSY isoform X22

    UniProtKB/TrEMBL
    D4AC97
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain
Nucleotide Protein Strain
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