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Lcmt1 leucine carboxyl methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361643, updated on 27-Nov-2024

Summary

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Official Symbol
Lcmt1provided by RGD
Official Full Name
leucine carboxyl methyltransferase 1provided by RGD
Primary source
RGD:735118
See related
EnsemblRapid:ENSRNOG00000014565 AllianceGenome:RGD:735118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein C-terminal leucine carboxyl O-methyltransferase activity. Predicted to be involved in regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to act upstream of or within several processes, including C-terminal protein methylation; negative regulation of protein-containing complex assembly; and regulation of glucose metabolic process. Predicted to be active in cytosol. Orthologous to human LCMT1 (leucine carboxyl methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 171.4), Brain (RPKM 163.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lcmt1 in Genome Data Viewer
Location:
1q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (187335173..187391195)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (177904119..177960111)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (193335629..193391620)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 11 Neighboring gene Rho GTPase activating protein 17 Neighboring gene uncharacterized LOC134483809 Neighboring gene aquaporin 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The structural basis for tight control of PP2A methylation and function by LCMT-1. Stanevich V, et al. Mol Cell, 2011 Feb 4. PMID 21292165, Free PMC Article
  2. HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia. Lei L, et al. Int J Mol Sci, 2022 Dec 17. PMID 36555780, Free PMC Article
  3. Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells. Lee JA, et al. J Biol Chem, 2007 Oct 19. PMID 17724024, Free PMC Article
  4. Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling. MacKay KB, et al. PLoS One, 2013. PMID 23840384, Free PMC Article
  5. Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue. De Baere I, et al. Biochemistry, 1999 Dec 14. PMID 10600115

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HIF-1alpha Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia.
    Title: HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia.
  2. A dominant-negative LCMT-1 mutant attenuates the cell cycle without causing cell death, likely by inhibiting uncontrolled phosphatase activity
    Title: The structural basis for tight control of PP2A methylation and function by LCMT-1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein C-terminal carboxyl O-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein C-terminal leucine carboxyl O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein C-terminal leucine carboxyl O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within C-terminal protein methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine carboxyl methyltransferase 1
Names
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
NP_955437.2
XP_006230253.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199405.3 → NP_955437.2  leucine carboxyl methyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q6P4Z6
    UniProtKB/TrEMBL
    A6I901
    Conserved Domains (1) summary
    pfam04072
    Location:24 → 215
    LCM; Leucine carboxyl methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    187335173..187391195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230191.5 → XP_006230253.1  leucine carboxyl methyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6V3
    Related
    ENSRNOP00000087959.1, ENSRNOT00000116935.2
    Conserved Domains (1) summary
    pfam04072
    Location:24 → 215
    LCM; Leucine carboxyl methyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P4Z6.1 GenPept UniProtKB/Swiss-Prot:Q6P4Z6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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