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Pwwp2b PWWP domain containing 2B [ Rattus norvegicus (Norway rat) ]

Gene ID: 361671, updated on 4-Jan-2025

Summary

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Official Symbol
Pwwp2bprovided by RGD
Official Full Name
PWWP domain containing 2Bprovided by RGD
Primary source
RGD:1307108
See related
EnsemblRapid:ENSRNOG00000036649 AllianceGenome:RGD:1307108
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pwwp2
Summary
Predicted to enable NuRD complex binding activity. Predicted to be involved in chromatin remodeling; positive regulation of transcription elongation by RNA polymerase II; and regulation of cold-induced thermogenesis. Predicted to be located in nucleoplasm. Orthologous to human PWWP2B (PWWP domain containing 2B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 127.5), Lung (RPKM 62.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pwwp2b in Genome Data Viewer
Location:
1q41
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (203470172..203489575)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194040395..194059979)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (211579706..211600715)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 32C Neighboring gene uncharacterized LOC120099954 Neighboring gene leucine rich repeat containing 27 Neighboring gene uncharacterized LOC134485192 Neighboring gene uncharacterized LOC134485193 Neighboring gene uncharacterized LOC134485195

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NuRD complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PWWP domain-containing protein 2B
Names
PWWP domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108507.2 → NP_001101977.1  PWWP domain-containing protein 2B

    See identical proteins and their annotated locations for NP_001101977.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162015
    UniProtKB/TrEMBL
    A0A8I5ZP22, B1WC60

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    203470172..203489575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230466.5 → XP_006230528.1  PWWP domain-containing protein 2B isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZP22, F7FFV6
    Related
    ENSRNOP00000023619.6, ENSRNOT00000023619.7
    Conserved Domains (1) summary
    cd05835
    Location:499 → 584
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

  2. XM_063267951.1 → XP_063124021.1  PWWP domain-containing protein 2B isoform X2

RNA

  1. XR_010054906.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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