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Sdhaf2 succinate dehydrogenase complex assembly factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361726, updated on 27-Nov-2024

Summary

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Official Symbol
Sdhaf2provided by RGD
Official Full Name
succinate dehydrogenase complex assembly factor 2provided by RGD
Primary source
RGD:1309216
See related
EnsemblRapid:ENSRNOG00000020646 AllianceGenome:RGD:1309216
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309216
Summary
Predicted to be involved in aerobic respiration; mitochondrial respiratory chain complex II assembly; and protein-FAD linkage. Predicted to act upstream of or within negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein dephosphorylation. Predicted to be located in cytosol and nucleolus. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SDHAF2 (succinate dehydrogenase complex assembly factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 258.3), Muscle (RPKM 236.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sdhaf2 in Genome Data Viewer
Location:
1q43
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216564002..216592877, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207139070..207167830, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226543671..226572414, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483971 Neighboring gene stabilizer of axonemal microtubules 4 Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene 5S ribosomal RNA Neighboring gene transmembrane protein 216

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-κB signaling pathway. Wu H, et al. Immunopharmacol Immunotoxicol, 2023 Jun. PMID 36326104
  2. Succinate dehydrogenase 5 (SDH5) regulates glycogen synthase kinase 3β-β-catenin-mediated lung cancer metastasis. Liu J, et al. J Biol Chem, 2013 Oct 11. PMID 23983127, Free PMC Article
  3. SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Hao HX, et al. Science, 2009 Aug 28. PMID 19628817, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-kappaB signaling pathway.
    Title: SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-κB signaling pathway.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC105864

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial electron transport, succinate to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, succinate to ubiquinone IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, succinate to ubiquinone ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial electron transport, succinate to ubiquinone ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial respiratory chain complex II assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex II assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-FAD linkage ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-FAD linkage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
succinate dehydrogenase assembly factor 2, mitochondrial
Names
SDH assembly factor 2
succinate dehydrogenase subunit 5, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008371.1 → NP_001008372.1  succinate dehydrogenase assembly factor 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001008372.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086542
    UniProtKB/Swiss-Prot
    Q5RJQ7
    UniProtKB/TrEMBL
    A0A8I6AIT7, A6I035
    Related
    ENSRNOP00000094094.1, ENSRNOT00000099357.2
    Conserved Domains (1) summary
    pfam03937
    Location:65 → 138
    Sdh5; Flavinator of succinate dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    216564002..216592877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589442.3 → XP_017444931.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZL70
    Conserved Domains (1) summary
    pfam03937
    Location:65 → 122
    Sdh5; Flavinator of succinate dehydrogenase

  2. XM_039084172.2 → XP_038940100.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZL70
    Conserved Domains (1) summary
    pfam03937
    Location:65 → 122
    Sdh5; Flavinator of succinate dehydrogenase

  3. XM_063268386.1 → XP_063124456.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X6

  4. XM_006231042.3 → XP_006231104.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I6AIT7
    Related
    ENSRNOP00000028028.5, ENSRNOT00000028028.6
    Conserved Domains (1) summary
    pfam03937
    Location:55 → 128
    Sdh5; Flavinator of succinate dehydrogenase

  5. XM_063268380.1 → XP_063124450.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X5

  6. XM_063268376.1 → XP_063124446.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X3

    Related
    ENSRNOP00000093612.1, ENSRNOT00000100064.2

  7. XM_063268367.1 → XP_063124437.1  succinate dehydrogenase assembly factor 2, mitochondrial isoform X1

    Related
    ENSRNOP00000101688.1, ENSRNOT00000129174.1

RNA

  1. XR_010055124.1 RNA Sequence

  2. XR_010055123.1 RNA Sequence

  3. XR_010055127.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RJQ7.1 GenPept UniProtKB/Swiss-Prot:Q5RJQ7

Gene LinkOut

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