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Mrps27 mitochondrial ribosomal protein S27 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361883, updated on 27-Nov-2024

Summary

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Official Symbol
Mrps27provided by RGD
Official Full Name
mitochondrial ribosomal protein S27provided by RGD
Primary source
RGD:1311829
See related
EnsemblRapid:ENSRNOG00000017272 AllianceGenome:RGD:1311829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mitochondrial ribosome binding activity; rRNA binding activity; and tRNA binding activity. Predicted to be involved in cell population proliferation and positive regulation of mitochondrial translation. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of mitochondrial small ribosomal subunit. Predicted to be active in mitochondrion. Orthologous to human MRPS27 (mitochondrial ribosomal protein S27). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 92.5), Adrenal (RPKM 83.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrps27 in Genome Data Viewer
Location:
2q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (32474178..32542741)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (30740007..30808577)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (29598344..29666711)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485827 Neighboring gene zinc finger protein 366 Neighboring gene pentatricopeptide repeat domain 2 Neighboring gene microtubule-associated protein 1B Neighboring gene uncharacterized LOC102553545

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes. Pu M, et al. Tumour Biol, 2017 Jul. PMID 28714366
  2. MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins. Davies SM, et al. FEBS Lett, 2012 Oct 19. PMID 22841715
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mitochondrial ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein mS27
Names
28S ribosomal protein S27, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108543.2 → NP_001102013.1  small ribosomal subunit protein mS27 isoform 2

    See identical proteins and their annotated locations for NP_001102013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' coding exons and uses a distinct 3' terminal exon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2K6X0, A6I563
    Related
    ENSRNOP00000073974.1, ENSRNOT00000088580.3
    Conserved Domains (1) summary
    pfam10037
    Location:1 → 94
    MRP-S27; Mitochondrial 28S ribosomal protein S27

  2. NM_001199192.1 → NP_001186121.1  small ribosomal subunit protein mS27 isoform 1

    See identical proteins and their annotated locations for NP_001186121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CB576151, DN934981, FM121157, JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I5ZNY6, A6I559, D4A3E8
    Related
    ENSRNOP00000023286.4, ENSRNOT00000023286.8
    Conserved Domains (2) summary
    sd00004
    Location:111 → 135
    PPR; PPR repeat [structural motif]
    pfam10037
    Location:1 → 406
    MRP-S27; Mitochondrial 28S ribosomal protein S27

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    32474178..32542741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102541.1 → XP_038958469.1  small ribosomal subunit protein mS27 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNY6
    Conserved Domains (1) summary
    pfam10037
    Location:1 → 341
    MRP-S27; Mitochondrial 28S ribosomal protein S27

  2. XM_039102540.1 → XP_038958468.1  small ribosomal subunit protein mS27 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNY6
    Conserved Domains (2) summary
    sd00004
    Location:51 → 75
    PPR; PPR repeat [structural motif]
    pfam10037
    Location:34 → 346
    MRP-S27; Mitochondrial 28S ribosomal protein S27

  3. XM_039102543.2 → XP_038958471.1  small ribosomal subunit protein mS27 isoform X3

    UniProtKB/TrEMBL
    A6I565
    Conserved Domains (1) summary
    pfam10037
    Location:1 → 259
    MRP-S27; Mitochondrial 28S ribosomal protein S27

  4. XM_039102542.2 → XP_038958470.1  small ribosomal subunit protein mS27 isoform X3

    UniProtKB/TrEMBL
    A6I565
    Conserved Domains (1) summary
    pfam10037
    Location:1 → 259
    MRP-S27; Mitochondrial 28S ribosomal protein S27

  5. XM_017590949.2 → XP_017446438.1  small ribosomal subunit protein mS27 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNY6
    Conserved Domains (2) summary
    sd00004
    Location:51 → 75
    PPR; PPR repeat [structural motif]
    pfam10037
    Location:34 → 346
    MRP-S27; Mitochondrial 28S ribosomal protein S27
Nucleotide Protein Strain
Heading Accession and Version

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