Postn periostin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Postnprovided by RGD
Official Full Name: periostinprovided by RGD
Primary source: RGD:1305285
See related: EnsemblRapid:ENSRNOG00000012660 AllianceGenome:RGD:1305285
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Plf
Summary: Predicted to enable cell adhesion molecule binding activity; heparin binding activity; and metal ion binding activity. Involved in several processes, including bone regeneration; negative regulation of cell-substrate adhesion; and positive regulation of chemokine (C-X-C motif) ligand 2 production. Located in extracellular space and neuromuscular junction. Used to study congestive heart failure. Biomarker of artery disease (multiple); degenerative disc disease; end stage renal disease; periodontitis; and tendinitis. Orthologous to human POSTN (periostin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 1495.9), Uterus (RPKM 1220.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (140677774..140709304)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (138527714..138559098)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (143656820..143688087)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

POSTN promotes nucleus pulposus cell senescence and extracellular matrix metabolism via activing Wnt/beta-catenin and NF-kappaB signal pathway in intervertebral disc degeneration.
Title: POSTN promotes nucleus pulposus cell senescence and extracellular matrix metabolism via activing Wnt/β-catenin and NF-κB signal pathway in intervertebral disc degeneration.
Self-amplifying loop of NF-kappaB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration.
Title: Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration.
Periostin aggravates the early phase of traumatic brain injury via the MAPK/ERK pathway.
Title: Periostin aggravates the early phase of traumatic brain injury via the MAPK/ERK pathway.
POSTN promotes diabetic vascular calcification by interfering with autophagic flux.
Title: POSTN promotes diabetic vascular calcification by interfering with autophagic flux.
Periostin promotes arterial calcification through PPARgamma-related glucose metabolism reprogramming.
Title: Periostin promotes arterial calcification through PPARγ-related glucose metabolism reprogramming.
Periostin aggravates NLRP3 inflammasome-mediated pyroptosis in myocardial ischemia-reperfusion injury.
Title: Periostin aggravates NLRP3 inflammasome-mediated pyroptosis in myocardial ischemia-reperfusion injury.
Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin.
Title: Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin.
Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats.
Title: Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats.
Periostin functions as a profibrotic and proinflammatory factor in nephron loss-associated chronic kidney disease. Periostin possibly triggers renal inflammation by restraining basal autophagic flux.
Title: Knockdown of periostin attenuates 5/6 nephrectomy-induced intrarenal renin-angiotensin system activation, fibrosis, and inflammation in rats.
Data show that the levels of periostin (Postn) in ovariectomy (OVX)-bone marrow mesenchymal stem cells (BMMSCs) were significantly reduced.
Title: Periostin-modified bone marrow mesenchymal stem cells from osteoporotic rats promote alveolar bone regeneration.

Submit: New GeneRIF Correction See all GeneRIFs (33)

General gene information

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Markers

RH143459 (e-PCR)
- UniSTS:232706

RH132037 (e-PCR)
- UniSTS:215320

AA997633 (e-PCR)
- UniSTS:261149

D0Mco29 (e-PCR)
- UniSTS:518789

AI747096 (e-PCR)
- UniSTS:178833

UniSTS:234679 (e-PCR)
- UniSTS:234679

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in bone regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin K	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: periostin

Names: periostin, osteoblast specific factor; periostin-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.