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Cryz crystallin zeta [ Rattus norvegicus (Norway rat) ]

Gene ID: 362061, updated on 27-Nov-2024

Summary

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Official Symbol
Cryzprovided by RGD
Official Full Name
crystallin zetaprovided by RGD
Primary source
RGD:1311639
See related
EnsemblRapid:ENSRNOG00000028319 AllianceGenome:RGD:1311639
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables mRNA 3'-UTR binding activity. Predicted to be involved in protein homotetramerization and xenobiotic catabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Orthologous to human CRYZ (crystallin zeta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 1109.1) and Liver (RPKM 84.2) See more
Orthologs
human mouse all
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Genomic context

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See Cryz in Genome Data Viewer
Location:
2q45
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (246211707..246239472)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (243552037..243580369)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (260884315..260911827)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 20 Neighboring gene voltage-dependent anion channel 1, pseudogene 14 Neighboring gene 40S ribosomal protein S7 pseudogene Neighboring gene tRNA-yW synthesizing protein 3 homolog Neighboring gene uncharacterized LOC120100979 Neighboring gene uncharacterized LOC102555516 Neighboring gene glutamate-rich 3 Neighboring gene transmembrane protein 14C pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. pH-responsive stabilization of glutamate dehydrogenase mRNA in LLC-PK1-F+ cells. Schroeder JM, et al. Am J Physiol Renal Physiol, 2003 Aug. PMID 12684230
  2. Human and yeast zeta-crystallins bind AU-rich elements in RNA. Fernández MR, et al. Cell Mol Life Sci, 2007 Jun. PMID 17497241, Free PMC Article
  3. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
  4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables NADH binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables NADH binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NADPH binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH binding IEA
Inferred from Electronic Annotation
more info
  
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NADPH:quinone reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH:quinone reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADPH:quinone reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables NADPH:quinone reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
quinone oxidoreductase
Names
NADPH:quinone reductase
crystallin, zeta (quinone reductase)
zeta-crystallin
NP_001012183.1
XP_006233582.1
XP_063138312.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012183.2 → NP_001012183.1  quinone oxidoreductase

    See identical proteins and their annotated locations for NP_001012183.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078927
    UniProtKB/Swiss-Prot
    Q6AYT0
    UniProtKB/TrEMBL
    A0A8I5Y5T4, A6HWQ3
    Related
    ENSRNOP00000103156.1, ENSRNOT00000124823.1
    Conserved Domains (2) summary
    cd08253
    Location:8 → 329
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
    COG0604
    Location:8 → 327
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    246211707..246239472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233520.5 → XP_006233582.1  quinone oxidoreductase isoform X1

    See identical proteins and their annotated locations for XP_006233582.1

    UniProtKB/Swiss-Prot
    Q6AYT0
    UniProtKB/TrEMBL
    A0A8I5Y5T4, A6HWQ3
    Conserved Domains (2) summary
    cd08253
    Location:8 → 329
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
    COG0604
    Location:8 → 327
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

  2. XM_063282242.1 → XP_063138312.1  quinone oxidoreductase isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYT0.1 GenPept UniProtKB/Swiss-Prot:Q6AYT0

Gene LinkOut

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