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Wls Wnt ligand secretion mediator [ Rattus norvegicus (Norway rat) ]

Gene ID: 362065, updated on 4-Jan-2025

Summary

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Symbol
Wlsprovided by RGD
Full Name
Wnt ligand secretion mediatorprovided by RGD
Primary source
RGD:735139
See related
EnsemblRapid:ENSRNOG00000036816 AllianceGenome:RGD:735139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr177
Summary
Enables mu-type opioid receptor binding activity. Involved in positive regulation of dendrite morphogenesis. Located in dendrite cytoplasm; dendrite membrane; and nucleus. Human ortholog(s) of this gene implicated in Zaki syndrome. Orthologous to human WLS (Wnt ligand secretion mediator). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 704.1), Kidney (RPKM 642.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wls in Genome Data Viewer
Location:
2q45
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (251590653..251705991)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (248931885..249047248)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (266315036..266431220)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556878 Neighboring gene transfer RNA isoleucine (anticodon AAU) 1 Neighboring gene succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons. Jaremko KM, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2014 Apr 3. PMID 24333843, Free PMC Article
  2. Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons. Reyes BA, et al. Exp Neurol, 2012 Jan. PMID 22001156, Free PMC Article
  3. Low expression of D2R and Wntless correlates with high motivation for heroin. Tacelosky DM, et al. Behav Neurosci, 2015 Dec. PMID 26501177, Free PMC Article
  4. Wntless in Wnt secretion: molecular, cellular and genetic aspects. Das S, et al. Front Biol (Beijing), 2012 Dec 1. PMID 23439944, Free PMC Article
  5. Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells. Jin J, et al. Dev Dyn, 2010 Sep. PMID 20652957, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results link reduced expression of both the D2R and Wntless to the explicit motivation for heroin rather than to differences in total drug intake per se
    Title: Low expression of D2R and Wntless correlates with high motivation for heroin.
  2. The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt secretion in a variety of embryonic and adult tissue types.
    Title: Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells.
  3. These findings suggest a previously unrecognized role for GPR177 in regulating cellular response to opioid agonist drugs, and could create new avenues of investigation regarding the pharmacotherapy of drug dependence.
    Title: Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
  
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mu-type opioid receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Wnt protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in anterior/posterior axis specification ISO
Inferred from Sequence Orthology
more info
  
involved_in anterior/posterior axis specification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cementum mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in exocrine pancreas development ISO
Inferred from Sequence Orthology
more info
  
involved_in hindbrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mesoderm formation ISO
Inferred from Sequence Orthology
more info
  
involved_in midbrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in organelle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein wntless homolog
Names
EVI
G protein-coupled receptor 177
evenness interrupted homolog
integral membrane protein GPR177
protein evenness interrupted homolog
wntless Wnt ligand secretion mediator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085353.1 → NP_001078822.1  protein wntless homolog

    See identical proteins and their annotated locations for NP_001078822.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC062391
    UniProtKB/Swiss-Prot
    Q6P689
    UniProtKB/TrEMBL
    A0A0G2K645
    Conserved Domains (1) summary
    pfam06664
    Location:178 → 496
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  2. NM_199408.3 → NP_955440.1  protein wntless homolog

    See identical proteins and their annotated locations for NP_955440.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q6P689
    UniProtKB/TrEMBL
    A0A0G2K645
    Related
    ENSRNOP00000052120.2, ENSRNOT00000055245.5
    Conserved Domains (1) summary
    pfam06664
    Location:178 → 496
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    251590653..251705991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102736.2 → XP_038958664.1  protein wntless homolog isoform X2

    UniProtKB/TrEMBL
    A0A0G2K645
    Conserved Domains (1) summary
    pfam06664
    Location:159 → 477
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  2. XM_039102737.2 → XP_038958665.1  protein wntless homolog isoform X1

    UniProtKB/TrEMBL
    A0A0G2K645, A6HWU8
    Conserved Domains (1) summary
    pfam06664
    Location:115 → 433
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P689.1 GenPept UniProtKB/Swiss-Prot:Q6P689

Gene LinkOut

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