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Ptpa protein phosphatase 2 phosphatase activator [ Rattus norvegicus (Norway rat) ]

Gene ID: 362102, updated on 27-Nov-2024

Summary

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Official Symbol
Ptpaprovided by RGD
Official Full Name
protein phosphatase 2 phosphatase activatorprovided by RGD
Primary source
RGD:1308354
See related
EnsemblRapid:ENSRNOG00000018457 AllianceGenome:RGD:1308354
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ppp2r4
Summary
Predicted to enable several functions, including ATP binding activity; protein homodimerization activity; and protein phosphatase 2A binding activity. Predicted to contribute to phosphoprotein phosphatase activity. Predicted to be involved in mitotic spindle organization and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be part of ATPase complex; calcium channel complex; and protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 422.8), Thymus (RPKM 400.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptpa in Genome Data Viewer
Location:
3p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34087637..34118100)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13689742..13720287)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8982122..9012585)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene dolichyldiphosphatase 1 Neighboring gene carnitine O-acetyltransferase Neighboring gene uncharacterized LOC120101516 Neighboring gene immediate early response 5-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure and mechanism of the phosphotyrosyl phosphatase activator. Chao Y, et al. Mol Cell, 2006 Aug. PMID 16916641
  2. Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis. Azam S, et al. Apoptosis, 2007 Jul. PMID 17333320
  3. Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the fast adaptive dendritic remodeling of underlying cortical neurons. Chen LJ, et al. J Neurotrauma, 2010 Sep. PMID 20568963
  4. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. Ogris E, et al. J Biol Chem, 1999 May 14. PMID 10318862, Free PMC Article
  5. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Marx SO, et al. Cell, 2000 May 12. PMID 10830164

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein phosphatase 2A, but not 2B, activity is downregulated following compressive injury of the cerebral cortex.
    Title: Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the fast adaptive dendritic remodeling of underlying cortical neurons.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ATPase complex ISO
Inferred from Sequence Orthology
more info
  
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A activator
Names
protein phosphatase 2 regulatory subunit 4
protein phosphatase 2A activator, regulatory subunit 4
protein phosphatase 2A regulatory subunit 4
protein phosphatase 2A, regulatory subunit B (PR 53)
NP_001102047.1
XP_038961297.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108577.2 → NP_001102047.1  serine/threonine-protein phosphatase 2A activator

    See identical proteins and their annotated locations for NP_001102047.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166861
    UniProtKB/TrEMBL
    B2RYQ2, F7FF51
    Related
    ENSRNOP00000104822.1, ENSRNOT00000128095.1
    Conserved Domains (1) summary
    pfam03095
    Location:26 → 316
    PTPA; Phosphotyrosyl phosphate activator (PTPA) protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    34087637..34118100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105369.2 → XP_038961297.1  serine/threonine-protein phosphatase 2A activator isoform X1

    Related
    ENSRNOP00000109918.1, ENSRNOT00000135308.1
    Conserved Domains (1) summary
    pfam03095
    Location:26 → 229
    PTPA; Phosphotyrosyl phosphate activator (PTPA) protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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