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Fubp3 far upstream element binding protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362106, updated on 9-Dec-2024

Summary

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Official Symbol
Fubp3provided by RGD
Official Full Name
far upstream element binding protein 3provided by RGD
Primary source
RGD:1307004
See related
EnsemblRapid:ENSRNOG00000009139 AllianceGenome:RGD:1307004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Marta2
Summary
Predicted to enable mRNA binding activity and single-stranded DNA binding activity. Involved in intracellular mRNA localization. Located in several cellular components, including dendritic shaft; neuronal cell body; and ribosome. Orthologous to human FUBP3 (far upstream element binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 126.1), Lung (RPKM 76.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fubp3 in Genome Data Viewer
Location:
3p12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (35253216..35302282)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14855527..14904540)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (10220712..10269757, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene hemicentin 2 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene argininosuccinate synthase 1 Neighboring gene PR/SET domain 12 Neighboring gene exosome component 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein engineering of a novel constitutively active hormone-receptor complex. Wu C, et al. J Biol Chem, 1996 Dec 6. PMID 8940183
  2. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. Davis-Smyth T, et al. J Biol Chem, 1996 Dec 6. PMID 8940189
  3. The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer. Weber A, et al. BMC Cancer, 2008 Dec 16. PMID 19087307, Free PMC Article
  4. The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons. Zivraj KH, et al. J Neurochem, 2013 Mar. PMID 23121659
  5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. in neurons MARTA2 appears to represent a key trans-acting factor involved in dendritic targeting of MAP2 mRNAs.
    Title: The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125009

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
far upstream element-binding protein 3
Names
MAP2 RNA trans-acting protein 2
far upstream element (FUSE) binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039337.2 → NP_001034426.2  far upstream element-binding protein 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JU26, G3V829, Q2QC85

  2. NM_001434291.1 → NP_001421220.1  far upstream element-binding protein 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6G4A0

  3. NM_001434292.1 → NP_001421221.1  far upstream element-binding protein 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6G4A0

  4. NM_001434293.1 → NP_001421222.1  far upstream element-binding protein 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JU26, G3V829, Q2QC85

  5. NM_001434294.1 → NP_001421223.1  far upstream element-binding protein 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6ACQ5, Q2QC85

  6. NM_001434295.1 → NP_001421224.1  far upstream element-binding protein 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6ATS5, Q2QC85

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    35253216..35302282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233924.5 → XP_006233986.1  far upstream element-binding protein 3 isoform X6

    Related
    ENSRNOP00000096689.1, ENSRNOT00000118843.2
    Conserved Domains (2) summary
    smart00322
    Location:161 → 232
    KH; K homology RNA-binding domain
    cd00105
    Location:79 → 141
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

  2. XM_063284068.1 → XP_063140138.1  far upstream element-binding protein 3 isoform X5

    UniProtKB/TrEMBL
    Q2QC85
    Related
    ENSRNOP00000089855.1, ENSRNOT00000104503.2

  3. XM_063284067.1 → XP_063140137.1  far upstream element-binding protein 3 isoform X4

    UniProtKB/TrEMBL
    Q2QC85

  4. XM_039105375.2 → XP_038961303.1  far upstream element-binding protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G4A0
    Related
    ENSRNOP00000078964.1, ENSRNOT00000102580.2
    Conserved Domains (4) summary
    cd22480
    Location:77 → 147
    KH-I_FUBP3_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
    cd22483
    Location:158 → 240
    KH-I_FUBP3_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
    cd22486
    Location:251 → 320
    KH-I_FUBP3_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
    cd22489
    Location:355 → 423
    KH-I_FUBP3_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins

  5. XM_063284066.1 → XP_063140136.1  far upstream element-binding protein 3 isoform X3

    Related
    ENSRNOP00000101214.1, ENSRNOT00000144831.1

  6. XM_006233921.5 → XP_006233983.1  far upstream element-binding protein 3 isoform X1

    Related
    ENSRNOP00000107880.1, ENSRNOT00000154414.1
    Conserved Domains (2) summary
    smart00322
    Location:161 → 232
    KH; K homology RNA-binding domain
    cd00105
    Location:79 → 141
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

  7. XM_006233922.5 → XP_006233984.1  far upstream element-binding protein 3 isoform X1

    Related
    ENSRNOP00000021871.6, ENSRNOT00000021871.9
    Conserved Domains (2) summary
    smart00322
    Location:161 → 232
    KH; K homology RNA-binding domain
    cd00105
    Location:79 → 141
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

  8. XM_039105376.2 → XP_038961304.1  far upstream element-binding protein 3 isoform X7

    UniProtKB/TrEMBL
    A0A8I6G4A0
    Conserved Domains (4) summary
    cd22483
    Location:72 → 154
    KH-I_FUBP3_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
    cd22486
    Location:165 → 234
    KH-I_FUBP3_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
    cd22489
    Location:269 → 337
    KH-I_FUBP3_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
    cl00098
    Location:1 → 61
    KH-I; K homology (KH) RNA-binding domain, type I

RNA

  1. XR_010064654.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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