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Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362152, updated on 4-Jan-2025

Summary

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Official Symbol
Hnrnpa3provided by RGD
Official Full Name
heterogeneous nuclear ribonucleoprotein A3provided by RGD
Primary source
RGD:727807
See related
EnsemblRapid:ENSRNOG00000052968 AllianceGenome:RGD:727807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
mBx; Hnrpa3
Summary
Enables RNA transmembrane transporter activity and mRNA binding activity. Involved in mRNA transport. Located in ribonucleoprotein granule. Part of ribonucleoprotein complex. Is active in glutamatergic synapse and postsynaptic density. Biomarker of silicosis. Orthologous to human HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 585.1), Spleen (RPKM 439.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hnrnpa3 in Genome Data Viewer
Location:
3q23
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (80984470..80999413)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (60578574..60588755)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (62481222..62491356)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101577 Neighboring gene uncharacterized LOC134486117 Neighboring gene uncharacterized LOC102554564 Neighboring gene NFE2 like bZIP transcription factor 2 Neighboring gene ribosomal protein L10, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a murine, major A/B type hnRNP protein: mBx. Plomaritoglou A, et al. Biochim Biophys Acta, 2000 Jan 31. PMID 10786617
  2. [Differential analysis of two-dimensional gel electrophoresis profiles in lung tissue of rats exposed to silica early]. Chen JJ, et al. Zhonghua Yu Fang Yi Xue Za Zhi, 2009 May. PMID 19534998
  3. Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition. Mori K, et al. EMBO Rep, 2016 Sep. PMID 27461252, Free PMC Article
  4. Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins. Percipalle P, et al. Nucleic Acids Res, 2002 Apr 15. PMID 11937625, Free PMC Article
  5. Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. Ma AS, et al. J Biol Chem, 2002 May 17. PMID 11886857

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neurons in the hippocampus of C9orf72 patients are frequently devoid of hnRNPA3. Reduced nuclear hnRNPA3 in the hippocampus of patients with extended C9orf72 repeats correlates with increased DPR deposition.
    Title: Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.
  2. has a role in cytoplasmic trafficking of RNA (heterogenous nuclear ribonucleoprotein A3)
    Title: Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein A3
Names
hnRNP A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111294.1 → NP_001104764.1  heterogeneous nuclear ribonucleoprotein A3 isoform a

    See identical proteins and their annotated locations for NP_001104764.1

    Status: VALIDATED

    Source sequence(s)
    AT006305, AW534817, BC081878, BI292197, BP488086, CB585714, CF110612, CF110891, CV107265, CV109437
    UniProtKB/Swiss-Prot
    Q6URK3, Q6URK4
    UniProtKB/TrEMBL
    A6HME5, D4A6A2
    Related
    ENSRNOP00000079420.2, ENSRNOT00000097068.2
    Conserved Domains (3) summary
    pfam11627
    Location:332 → 348
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36 → 113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126 → 205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

  2. NM_001111295.1 → NP_001104765.1  heterogeneous nuclear ribonucleoprotein A3 isoform b

    See identical proteins and their annotated locations for NP_001104765.1

    Status: VALIDATED

    Source sequence(s)
    BC081878, CB585714, CB725005
    UniProtKB/TrEMBL
    A6HME9, D4A6A2
    Conserved Domains (3) summary
    pfam11627
    Location:310 → 326
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:104 → 183
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12763
    Location:11 → 91
    RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

  3. NM_198132.3 → NP_937765.1  heterogeneous nuclear ribonucleoprotein A3 isoform a

    See identical proteins and their annotated locations for NP_937765.1

    Status: VALIDATED

    Source sequence(s)
    BC081878, CB585714
    UniProtKB/Swiss-Prot
    Q6URK3, Q6URK4
    UniProtKB/TrEMBL
    A6HME5, D4A6A2
    Conserved Domains (3) summary
    pfam11627
    Location:332 → 348
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36 → 113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126 → 205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    80984470..80999413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284131.1 → XP_063140201.1  heterogeneous nuclear ribonucleoprotein A3 isoform X1

    UniProtKB/Swiss-Prot
    Q6URK3, Q6URK4
    UniProtKB/TrEMBL
    A6HME5, D4A6A2

  2. XM_063284134.1 → XP_063140204.1  heterogeneous nuclear ribonucleoprotein A3 isoform X3

    UniProtKB/TrEMBL
    A6HME9, D4A6A2

  3. XM_063284132.1 → XP_063140202.1  heterogeneous nuclear ribonucleoprotein A3 isoform X2

  4. XM_008761911.4 → XP_008760133.1  heterogeneous nuclear ribonucleoprotein A3 isoform X3

    See identical proteins and their annotated locations for XP_008760133.1

    UniProtKB/TrEMBL
    A6HME9, D4A6A2
    Conserved Domains (3) summary
    pfam11627
    Location:310 → 326
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:104 → 183
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12763
    Location:11 → 91
    RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

  5. XM_008761912.4 → XP_008760134.1  heterogeneous nuclear ribonucleoprotein A3 isoform X3

    See identical proteins and their annotated locations for XP_008760134.1

    UniProtKB/TrEMBL
    A6HME9, D4A6A2
    Conserved Domains (3) summary
    pfam11627
    Location:310 → 326
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:104 → 183
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12763
    Location:11 → 91
    RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6URK4.1 GenPept UniProtKB/Swiss-Prot:Q6URK4

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