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zetaTry zetaTrypsin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36216, updated on 9-Dec-2024

Summary

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Official Symbol
zetaTryprovided by FlyBase
Official Full Name
zetaTrypsinprovided by FlyBase
Primary source
FLYBASE:FBgn0011556
Locus tag
Dmel_CG12387
See related
AllianceGenome:FB:FBgn0011556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12387; Dmel\CG12387; DmZetaTry; SP110; ZetaTry; zetaTryp
Summary
Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in organism. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See zetaTry in Genome Data Viewer
Location:
47F3-47F3; 2-64 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11339186..11340132, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7226691..7227637, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lambdaTry Neighboring gene kappaTry Neighboring gene etaTrypsin Neighboring gene thetaTrypsin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Behavioural Effects and RNA-seq Analysis of Aβ42-Mediated Toxicity in a Drosophila Alzheimer's Disease Model. Tan FHP, et al. Mol Neurobiol, 2023 Aug. PMID 37145377
  2. In Drosophila Hemolymph, Serine Proteases Are the Major Gelatinases and Caseinases. Gatti JL, et al. Insects, 2024 Mar 28. PMID 38667364, Free PMC Article
  3. Concerted evolution within a trypsin gene cluster in Drosophila. Wang S, et al. Mol Biol Evol, 1999 Sep. PMID 10486967
  4. A novel interplay between the ubiquitin–proteasome system and serine proteases during Drosophila development. Lipinszki Z, et al. Biochem J, 2013 Sep 15. PMID 23805892
  5. The digestive tract of Drosophila melanogaster. Lemaitre B, et al. Annu Rev Genet, 2013. PMID 24016187

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
zetaTrypsin
Names
CG12387-PA
zetaTry-PA
NP_523691.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11339186..11340132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078967.4 → NP_523691.1  zetaTrypsin [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523691.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42280, Q9V5X8
    Related
    FBpp0087260
    Conserved Domains (2) summary
    smart00020
    Location:38 → 273
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:39 → 276
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42280.2 P42280

Gene LinkOut

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