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Prr5l proline rich 5 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 362171, updated on 9-Dec-2024

Summary

Official Symbol
Prr5lprovided by RGD
Official Full Name
proline rich 5 likeprovided by RGD
Primary source
RGD:1309969
See related
EnsemblRapid:ENSRNOG00000004666 AllianceGenome:RGD:1309969
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Protor2; Protor-2; RGD1309969
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including TORC2 signaling; positive regulation of intracellular protein transport; and regulation of fibroblast migration. Predicted to act upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and positive regulation of protein phosphorylation. Predicted to be part of TORC2 complex. Orthologous to human PRR5L (proline rich 5 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 55.7), Spleen (RPKM 26.1) and 9 other tissues See more
Orthologs
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Genomic context

See Prr5l in Genome Data Viewer
Location:
3q31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (108458107..108628552, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (88001951..88173532, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (91290207..91461208, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene recombination activating 1 Neighboring gene TNF receptor associated factor 6 Neighboring gene COMM domain containing 9 Neighboring gene uncharacterized LOC134486413 Neighboring gene low density lipoprotein receptor class A domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in TORC2 signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in TORC2 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in TORC2 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fibroblast migration ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
 
part_of TORC2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of TORC2 complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proline-rich protein 5-like
Names
protein observed with Rictor-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080150.1NP_001073619.1  proline-rich protein 5-like

    See identical proteins and their annotated locations for NP_001073619.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129104
    UniProtKB/Swiss-Prot
    A1L1K1
    UniProtKB/TrEMBL
    A0A8I5ZMF5
    Related
    ENSRNOP00000006291.7, ENSRNOT00000006291.9
    Conserved Domains (1) summary
    pfam08539
    Location:49168
    HbrB; HbrB-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    108458107..108628552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591900.3XP_017447389.1  proline-rich protein 5-like isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZMF5, F1LQP5
    Conserved Domains (1) summary
    pfam08539
    Location:49168
    HbrB; HbrB-like
  2. XM_039105436.2XP_038961364.1  proline-rich protein 5-like isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZMF5, F1LQP5
    Conserved Domains (1) summary
    pfam08539
    Location:49168
    HbrB; HbrB-like
  3. XM_006234647.5XP_006234709.1  proline-rich protein 5-like isoform X1

    See identical proteins and their annotated locations for XP_006234709.1

    UniProtKB/TrEMBL
    A0A8I5ZMF5, F1LQP5
    Conserved Domains (1) summary
    pfam08539
    Location:49168
    HbrB; HbrB-like