Nop56 NOP56 ribonucleoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nop56provided by RGD
Official Full Name: NOP56 ribonucleoproteinprovided by RGD
Primary source: RGD:1308892
See related: EnsemblRapid:ENSRNOG00000007128 AllianceGenome:RGD:1308892
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nol5a
Summary: Predicted to enable histone methyltransferase binding activity and snoRNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in fibrillar center. Predicted to be part of box C/D methylation guide snoRNP complex; pre-snoRNP complex; and small-subunit processome. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 36. Orthologous to human NOP56 (NOP56 ribonucleoprotein). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 288.8), Spleen (RPKM 269.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (137926187..137934971)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (117476963..117481847)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (122803726..122808564)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nol5a expands the link between Myc-induced regulation of nucleolar target genes
Title: Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase binding	ISO Inferred from Sequence Orthology more info
enables snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables snoRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of box C/D methylation guide snoRNP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
part_of pre-snoRNP complex	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of sno(s)RNA-containing ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleolar protein 56

Names: NOP56 ribonucleoprotein homolog; nucleolar protein 5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025732.1 → NP_001020903.1 nucleolar protein 56

See identical proteins and their annotated locations for NP_001020903.1

Status: PROVISIONAL

Source sequence(s)

BC099149

UniProtKB/TrEMBL

F7FCF9, Q4KLK7, Q5RJN5

Related

ENSRNOP00000009563.4, ENSRNOT00000009564.7

Conserved Domains (3) summary

smart00931
Location:168 → 219

NOSIC; NOSIC (NUC001) domain

COG1498
Location:48 → 416

SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]

pfam08156
Location:5 → 70

NOP5NT; NOP5NT (NUC127) domain