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Cenpb centromere protein B [ Rattus norvegicus (Norway rat) ]

Gene ID: 362217, updated on 4-Jan-2025

Summary

Official Symbol
Cenpbprovided by RGD
Official Full Name
centromere protein Bprovided by RGD
Primary source
RGD:1304794
See related
EnsemblRapid:ENSRNOG00000057284 AllianceGenome:RGD:1304794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity. Predicted to be located in condensed chromosome, centromeric region; nuclear body; and pericentric heterochromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in inner ear disease and primary biliary cholangitis. Orthologous to human CENPB (centromere protein B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Cenpb in Genome Data Viewer
Location:
3q36
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138850003..138852796, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118396987..118399780, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123720888..123723520, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene adipose secreted signaling protein Neighboring gene sperm flagellar 1 Neighboring gene uncharacterized LOC134486156 Neighboring gene cell division cycle 25B

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
located_in condensed chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
major centromere autoantigen B
Names
centromere autoantigen B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399319.1NP_001386248.1  major centromere autoantigen B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2KAW9
    Related
    ENSRNOP00000075557.2, ENSRNOT00000080351.3
    Conserved Domains (4) summary
    smart00674
    Location:74135
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    pfam09026
    Location:543602
    CENP-B_dimeris; Centromere protein B dimerization domain
    pfam03184
    Location:222384
    DDE_1; DDE superfamily endonuclease
    pfam04218
    Location:256
    CENP-B_N; CENP-B N-terminal DNA-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    138850003..138852796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)