U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dido1 death inducer-obliterator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362286, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Dido1provided by RGD
Official Full Name
death inducer-obliterator 1provided by RGD
Primary source
RGD:1311173
See related
EnsemblRapid:ENSRNOG00000009936 AllianceGenome:RGD:1311173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Datf1
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within apoptotic signaling pathway. Predicted to be active in nucleus. Orthologous to human DIDO1 (death inducer-obliterator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 118.7), Spleen (RPKM 112.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dido1 in Genome Data Viewer
Location:
3q43
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188150100..188203445, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167772535..167825894, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176162886..176216868, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transcription factor like 5 Neighboring gene ATP synthase membrane subunit f, pseudogene 2 Neighboring gene GID complex subunit 8 homolog Neighboring gene solute carrier family 17 member 9 Neighboring gene basic helix-loop-helix family, member e23

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. García-Domingo D, et al. Proc Natl Acad Sci U S A, 1999 Jul 6. PMID 10393935, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
death-inducer obliterator 1
Names
death associated transcription factor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427308.1 → NP_001414237.1  death-inducer obliterator 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZXE0
    Related
    ENSRNOP00000082610.1, ENSRNOT00000113048.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    188150100..188203445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235806.5 → XP_006235868.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006235868.1

    UniProtKB/TrEMBL
    A0A8I5ZXE0, A6KM85
    Conserved Domains (7) summary
    smart00510
    Location:671 → 772
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PHA03247
    Location:1564 → 2085
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157 → 299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:2144 → 2182
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1046 → 1194
    SPOC; SPOC domain
    pfam16495
    Location:1465 → 1502
    SWIRM-assoc_1; SWIRM-associated region 1

  2. XM_008762595.4 → XP_008760817.1  death-inducer obliterator 1 isoform X2

    See identical proteins and their annotated locations for XP_008760817.1

    UniProtKB/TrEMBL
    A6KM85, D3ZWL9
    Related
    ENSRNOP00000013189.6, ENSRNOT00000013189.10
    Conserved Domains (6) summary
    smart00510
    Location:632 → 733
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam01749
    Location:138 → 241
    IBB; Importin beta binding domain
    pfam02724
    Location:143 → 192
    CDC45; CDC45-like protein
    pfam07744
    Location:1015 → 1121
    SPOC; SPOC domain
    pfam16495
    Location:1425 → 1463
    SWIRM-assoc_1; SWIRM-associated region 1

  3. XM_063284235.1 → XP_063140305.1  death-inducer obliterator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZXE0

  4. XM_039106760.2 → XP_038962688.1  death-inducer obliterator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZXE0, A6KM85
    Conserved Domains (7) summary
    smart00510
    Location:671 → 772
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PHA03247
    Location:1564 → 2085
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157 → 299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:2144 → 2182
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1046 → 1194
    SPOC; SPOC domain
    pfam16495
    Location:1465 → 1502
    SWIRM-assoc_1; SWIRM-associated region 1

  5. XM_006235807.5 → XP_006235869.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006235869.1

    UniProtKB/TrEMBL
    A0A8I5ZXE0, A6KM85
    Conserved Domains (7) summary
    smart00510
    Location:671 → 772
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PHA03247
    Location:1564 → 2085
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157 → 299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:2144 → 2182
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1046 → 1194
    SPOC; SPOC domain
    pfam16495
    Location:1465 → 1502
    SWIRM-assoc_1; SWIRM-associated region 1

  6. XM_063284236.1 → XP_063140306.1  death-inducer obliterator 1 isoform X4

  7. XM_008762596.4 → XP_008760818.1  death-inducer obliterator 1 isoform X3

    See identical proteins and their annotated locations for XP_008760818.1

    Conserved Domains (5) summary
    smart00510
    Location:671 → 772
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1054 → 1160
    SPOC; SPOC domain
    pfam08619
    Location:147 → 262
    Nha1_C; Alkali metal cation/H+ antiporter Nha1 C terminus
    pfam15727
    Location:858 → 1040
    DUF4678; Domain of unknown function (DUF4678)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108612.1: Suppressed sequence

    Description
    NM_001108612.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: DIDO1 (GeneID:11083).
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools