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Mios meiosis regulator for oocyte development [ Rattus norvegicus (Norway rat) ]

Gene ID: 362324, updated on 4-Jan-2025

Summary

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Official Symbol
Miosprovided by RGD
Official Full Name
meiosis regulator for oocyte developmentprovided by RGD
Primary source
RGD:1308432
See related
EnsemblRapid:ENSRNOG00000007924 AllianceGenome:RGD:1308432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308432
Summary
Predicted to be involved in several processes, including cellular response to amino acid starvation; gliogenesis; and positive regulation of TORC1 signaling. Predicted to be located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Predicted to be part of GATOR2 complex. Predicted to be active in cytoplasm. Orthologous to human MIOS (meiosis regulator for oocyte development). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 75.0), Spleen (RPKM 73.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mios in Genome Data Viewer
Location:
4q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (37229533..37255862)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (36263419..36289546)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (34238370..34264015)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550307 Neighboring gene collagen type XXVIII alpha 1 chain Neighboring gene uncharacterized LOC134486727 Neighboring gene glucocorticoid induced 1 Neighboring gene replication protein A3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of mTORC1 by amino acids. Bar-Peled L, et al. Trends Cell Biol, 2014 Jul. PMID 24698685, Free PMC Article
  2. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Bar-Peled L, et al. Science, 2013 May 31. PMID 23723238, Free PMC Article
  3. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Wolfson RL, et al. Nature, 2017 Mar 16. PMID 28199306, Free PMC Article
  4. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system myelin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in oligodendrocyte progenitor proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of GATOR2 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GATOR2 complex protein MIOS
Names
GATOR complex protein MIOS
WD repeat-containing protein mio
missing oocyte, meiosis regulator, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173554.1 → NP_001167025.1  GATOR2 complex protein MIOS

    See identical proteins and their annotated locations for NP_001167025.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    D3Z9C0
    Related
    ENSRNOP00000010952.4, ENSRNOT00000010952.7
    Conserved Domains (3) summary
    sd00039
    Location:64 → 105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:782 → 858
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
    cl29593
    Location:112 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    37229533..37255862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107768.2 → XP_038963696.1  GATOR2 complex protein MIOS isoform X1

    UniProtKB/TrEMBL
    D3Z9C0
    Conserved Domains (3) summary
    sd00039
    Location:64 → 105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:782 → 858
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
    cl29593
    Location:112 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006236090.5 → XP_006236152.1  GATOR2 complex protein MIOS isoform X1

    See identical proteins and their annotated locations for XP_006236152.1

    UniProtKB/TrEMBL
    D3Z9C0
    Conserved Domains (3) summary
    sd00039
    Location:64 → 105
    7WD40; WD40 repeat [structural motif]
    cd16691
    Location:782 → 858
    mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
    cl29593
    Location:112 → 299
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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