Flnc filamin C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Flncprovided by RGD
Official Full Name: filamin Cprovided by RGD
Primary source: RGD:1308807
See related: EnsemblRapid:ENSRNOG00000007281 AllianceGenome:RGD:1308807
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ABP-L; FLN-C
Summary: Enables ankyrin binding activity. Predicted to be involved in sarcomere organization. Located in sarcolemma and sarcoplasm. Human ortholog(s) of this gene implicated in distal myopathy 4; hypertrophic cardiomyopathy 26; and myofibrillar myopathy 5. Orthologous to human FLNC (filamin C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 1653.1), Heart (RPKM 585.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (58999445..59027240)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (58034088..58061882)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (56710934..56738779)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

physical interaction between RasGAP and FLN-C facilitates an interaction between G3BP and cdk7 mRNA
Title: An alliance between Ras GTPase-activating protein, filamin C, and Ras GTPase-activating protein SH3 domain-binding protein regulates myocyte growth.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables ankyrin binding	IEA Inferred from Electronic Annotation more info
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in costamere	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intracellular membraneless organelle	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: filamin-C

Names: ABP-280-like protein; actin-binding-like protein; filamin C, gamma (actin binding protein 280); filamin-2; gamma-filamin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191862.1 → NP_001178791.1 filamin-C

See identical proteins and their annotated locations for NP_001178791.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

D3ZHA0

UniProtKB/TrEMBL

A0A8L2R384

Related

ENSRNOP00000027237.7, ENSRNOT00000027237.9

Conserved Domains (4) summary

smart00033
Location:166 → 258

CH; Calponin homology domain

smart00557
Location:1863 → 1949

IG_FLMN; Filamin-type immunoglobulin domains

cd00014
Location:38 → 142

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00630
Location:1857 → 1944

Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

58999445..59027240

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107774.2 → XP_038963702.1 filamin-C isoform X1

UniProtKB/TrEMBL

A0A8L2R384

Conserved Domains (4) summary

smart00557
Location:1884 → 1970

IG_FLMN; Filamin-type immunoglobulin domains

pfam00630
Location:2429 → 2515

Filamin; Filamin/ABP280 repeat

cd21310
Location:23 → 147

CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

cd21314
Location:151 → 265

CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
XM_039107775.2 → XP_038963703.1 filamin-C isoform X2

UniProtKB/TrEMBL

A0A8L2R384

Conserved Domains (4) summary

smart00557
Location:1851 → 1937

IG_FLMN; Filamin-type immunoglobulin domains

pfam00630
Location:2396 → 2482

Filamin; Filamin/ABP280 repeat

cd21310
Location:23 → 147

CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

cd21314
Location:151 → 265

CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
XM_006236214.5 → XP_006236276.1 filamin-C isoform X3

UniProtKB/TrEMBL

A0A0H2UHR7, A0A8L2R384

Related

ENSRNOP00000079220.2, ENSRNOT00000098293.2

Conserved Domains (4) summary

smart00033
Location:166 → 258

CH; Calponin homology domain

smart00557
Location:1830 → 1916

IG_FLMN; Filamin-type immunoglobulin domains

cd00014
Location:38 → 142

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00630
Location:1824 → 1911

Filamin; Filamin/ABP280 repeat