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Smyd4-3 SET and MYND domain containing, class 4, member 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36234, updated on 9-Dec-2024

Summary

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Official Symbol
Smyd4-3provided by FlyBase
Official Full Name
SET and MYND domain containing, class 4, member 3provided by FlyBase
Primary source
FLYBASE:FBgn0033633
Locus tag
Dmel_CG7759
See related
AllianceGenome:FB:FBgn0033633
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7759; Dmel\CG7759
Summary
Predicted to enable histone H3K4 methyltransferase activity and histone deacetylase binding activity. Involved in compound eye photoreceptor development. Located in cytoplasm. Is expressed in larval somatic muscle cell and mesoderm. Orthologous to human SMYD4 (SET and MYND domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Smyd4-3 in Genome Data Viewer
Location:
47F10-47F10; 2-64 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11405597..11408079)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7293102..7295584)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Threonine-TGT 2-3 Neighboring gene transfer RNA:Threonine-TGT 2-4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression and function of an aquaporin. Bergland AO, et al. PLoS Genet, 2012. PMID 22509142, Free PMC Article
  2. Generation and characterization of new alleles of quiver (qvr) that encodes an extracellular modulator of the Shaker potassium channel. Ruan H, et al. J Neurogenet, 2017 Dec. PMID 29117754, Free PMC Article
  3. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
  4. Enhancer-promoter communication at the Drosophila engrailed locus. Kwon D, et al. Development, 2009 Sep. PMID 19675130, Free PMC Article
  5. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. Thompson EC, et al. PLoS One, 2008 Aug 20. PMID 18714374, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone H3K4 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in compound eye photoreceptor development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in compound eye photoreceptor development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SET and MYND domain containing, class 4, member 3
Names
CG7759-PA
Smyd4-3-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11405597..11408079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165831.3 → NP_725048.1  SET and MYND domain containing, class 4, member 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725048.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8L3, Q95RZ8
    Related
    FBpp0087232
    Conserved Domains (3) summary
    sd00006
    Location:74 → 103
    TPR; TPR repeat [structural motif]
    pfam01753
    Location:284 → 323
    zf-MYND; MYND finger
    pfam13414
    Location:74 → 143
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z8L3 A1Z8L3
Q95RZ8 Q95RZ8

Gene LinkOut

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