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Prip prip [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36237, updated on 4-Jan-2025

Summary

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Official Symbol
Pripprovided by FlyBase
Official Full Name
pripprovided by FlyBase
Primary source
FLYBASE:FBgn0033635
Locus tag
Dmel_CG7777
See related
AllianceGenome:FB:FBgn0033635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aqp7777; CG7777; Dmel\CG7777
Summary
Enables water channel activity. Involved in water transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including adult Malpighian tubule stellate cell of main segment; adult head; epithelium; ganglia; and germline cell. Human ortholog(s) of this gene implicated in Bothnian type palmoplantar keratoderma; nephrogenic diabetes insipidus; and nephrogenic diabetes insipidus type 2. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)); AQP2 (aquaporin 2); and AQP5 (aquaporin 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Prip in Genome Data Viewer
Location:
47F12-47F13; 2-64 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11436243..11442216)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7323748..7329721)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene drip Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43771 Neighboring gene quiver Neighboring gene Enhancer of Polycomb

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ageing and genetic background influence anaesthetic effects in a D. melanogaster model of blunt trauma with brain injury(†). Schiffman HJ, et al. Br J Anaesth, 2020 Jul. PMID 32466842, Free PMC Article
  2. Reactive Oxygen Species Mediate Activity-Regulated Dendritic Plasticity Through NADPH Oxidase and Aquaporin Regulation. Dhawan S, et al. Front Cell Neurosci, 2021. PMID 34290589, Free PMC Article
  3. Developmental expression and biophysical characterization of a Drosophila melanogaster aquaporin. Kaufmann N, et al. Am J Physiol Cell Physiol, 2005 Aug. PMID 15800049
  4. Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases. Sobrido-Cameán D, et al. Front Cell Neurosci, 2022. PMID 36713781, Free PMC Article
  5. Osmolarity-regulated swelling initiates egg activation in Drosophila. York-Andersen AH, et al. Open Biol, 2021 Aug. PMID 34343463, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables channel activity IEA
Inferred from Electronic Annotation
more info
  
enables channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables water channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in water transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prip
Names
CG7777-PA
CG7777-PB
CG7777-PC
CG7777-PD
Prip-PA
Prip-PB
Prip-PC
Prip-PD
aquaporin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11436243..11442216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136842.4 → NP_610686.1  prip, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610686.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TS2
    Related
    FBpp0087235
    Conserved Domains (1) summary
    cl00200
    Location:12 → 226
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  2. NM_001259337.2 → NP_001246266.1  prip, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246266.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMU9
    Conserved Domains (1) summary
    cl00200
    Location:12 → 226
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  3. NM_001299388.1 → NP_001286317.1  prip, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286317.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    J7K3P9
    Conserved Domains (1) summary
    cl00200
    Location:12 → 226
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  4. NM_165834.3 → NP_725052.1  prip, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725052.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8L8
    Related
    FBpp0087236
    Conserved Domains (1) summary
    cl00200
    Location:12 → 226
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z8L8 A1Z8L8
D3DMU9 D3DMU9
J7K3P9 J7K3P9
Q95TS2 Q95TS2

Gene LinkOut

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