tou toutatis [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: touprovided by FlyBase
Official Full Name: toutatisprovided by FlyBase
Primary source: FLYBASE:FBgn0033636
Locus tag: Dmel_CG10897
See related: AllianceGenome:FB:FBgn0033636
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-48Ad; CG10897; Dm Tou; Dmel\CG10897; EP(2)0622; EP0622; EP622; gene VI; TIP5; Tou; TOU; VI
Summary: Enables DNA-binding transcription factor binding activity. Involved in chromatin remodeling; nervous system development; and positive regulation of transcription by RNA polymerase II. Part of ISWI-type complex. Colocalizes with polytene chromosome. Is expressed in several structures, including central brain primordium; ganglia; glial cell; gut section; and spermatozoon. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A) and BAZ2B (bromodomain adjacent to zinc finger domain 2B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 48A1-48A3; 2-64 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11577485..11616045, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7464990..7503550, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Toutatis forms two alternative complexes that have differential distribution and can participate in distinct aspects of nuclear DNA metabolism.
Title: Identification and characterization of ToRC, a novel ISWI-containing ATP-dependent chromatin assembly complex.
Tou acts positively to activate proneural gene expression.
Title: Toutatis, a TIP5-related protein, positively regulates Pannier function during Drosophila neural development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ISWI-type complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: toutatis

Names: CG10897-PA; CG10897-PB; CG10897-PE; CG10897-PF; CG10897-PG; tou-PA; tou-PB; tou-PE; tou-PF; tou-PG; transcript group VI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

11577485..11616045 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273969.1 → NP_001260898.1 toutatis, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260898.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFE3, Q9BMQ0

Conserved Domains (10) summary

cd05503
Location:2954 → 3050

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

cd01397
Location:895 → 969

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

sd00025
Location:2567 → 2586

zf-RanBP2; RanBP2-type Zn finger [structural motif]

sd00029
Location:2607 → 2625

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd15545
Location:2567 → 2612

PHD_BAZ2A_like; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) and 2B (BAZ2B)

pfam00628
Location:2622 → 2671

PHD; PHD-finger

pfam02791
Location:1182 → 1244

DDT; DDT domain

pfam15612
Location:1333 → 1382

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15614
Location:2117 → 2151

WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

cl23765
Location:1007 → 1070

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_078977.5 → NP_523701.3 toutatis, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523701.3

Status: REVIEWED

UniProtKB/TrEMBL

A1Z8M2, Q9BMQ0

Conserved Domains (12) summary

cd05503
Location:2895 → 2991

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

cd01397
Location:953 → 1027

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

sd00025
Location:2508 → 2527

zf-RanBP2; RanBP2-type Zn finger [structural motif]

sd00029
Location:2548 → 2566

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd15545
Location:2508 → 2553

PHD_BAZ2A_like; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) and 2B (BAZ2B)

pfam00628
Location:2563 → 2612

PHD; PHD-finger

pfam02791
Location:1255 → 1317

DDT; DDT domain

pfam05672
Location:1043 → 1198

MAP7; MAP7 (E-MAP-115) family

pfam15612
Location:1406 → 1455

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15614
Location:2190 → 2224

WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

cl01146
Location:1021 → 1127

ZapA; Cell division protein ZapA

cl23720
Location:1085 → 1179

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001103800.3 → NP_001097270.1 toutatis, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097270.1

Status: REVIEWED

UniProtKB/TrEMBL

A8DYA3, Q9BMQ0

Conserved Domains (12) summary

cd05503
Location:3027 → 3123

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

cd01397
Location:953 → 1027

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

sd00025
Location:2640 → 2659

zf-RanBP2; RanBP2-type Zn finger [structural motif]

sd00029
Location:2680 → 2698

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd15545
Location:2640 → 2685

PHD_BAZ2A_like; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) and 2B (BAZ2B)

pfam00628
Location:2695 → 2744

PHD; PHD-finger

pfam02791
Location:1255 → 1317

DDT; DDT domain

pfam05672
Location:1043 → 1198

MAP7; MAP7 (E-MAP-115) family

pfam15612
Location:1406 → 1455

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15614
Location:2190 → 2224

WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

cl01146
Location:1021 → 1127

ZapA; Cell division protein ZapA

cl23720
Location:1085 → 1179

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001273970.1 → NP_001260899.1 toutatis, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260899.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEM1, Q9BMQ0

Conserved Domains (10) summary

cd05503
Location:2990 → 3086

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

cd01397
Location:953 → 1027

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

sd00025
Location:2603 → 2622

zf-RanBP2; RanBP2-type Zn finger [structural motif]

sd00029
Location:2643 → 2661

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd15545
Location:2603 → 2648

PHD_BAZ2A_like; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) and 2B (BAZ2B)

pfam00628
Location:2658 → 2707

PHD; PHD-finger

pfam02791
Location:1218 → 1280

DDT; DDT domain

pfam15612
Location:1369 → 1418

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15614
Location:2153 → 2187

WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

cl15166
Location:1071 → 1159

RRP7_like; RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p), ribosomal RNA-processing protein 7 homolog A (Rrp7A), and similar proteins
NM_165844.2 → NP_725062.2 toutatis, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725062.2

Status: REVIEWED

UniProtKB/TrEMBL

Q95T46

Related

FBpp0087196

Conserved Domains (1) summary

cd05503
Location:145 → 241

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...