Tada3 transcriptional adaptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tada3provided by RGD
Official Full Name: transcriptional adaptor 3provided by RGD
Primary source: RGD:1564009
See related: EnsemblRapid:ENSRNOG00000008597 AllianceGenome:RGD:1564009
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tada3l
Summary: Predicted to enable nuclear receptor binding activity; nuclear receptor coactivator activity; and protein domain specific binding activity. Predicted to be involved in several processes, including regulation of cell division; regulation of embryonic development; and regulation of gene expression. Predicted to act upstream of or within several processes, including chromatin organization; regulation of protein modification process; and regulation of protein stability. Predicted to be located in mitotic spindle and nucleoplasm. Predicted to be part of ATAC complex; SAGA complex; and transcription factor TFTC complex. Orthologous to human TADA3 (transcriptional adaptor 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 106.6), Lung (RPKM 81.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (148065859..148077347, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (146510213..146521975, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (145318417..145330291, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH127415 (e-PCR)
- UniSTS:210725

PMC117179P1 (e-PCR)
- UniSTS:270317

UniSTS:238061 (e-PCR)
- UniSTS:238061

AI987856 (e-PCR)
- UniSTS:164336

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within chromatin organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA complex	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFTC complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcriptional adapter 3

Names: ADA3 homolog; ADA3-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025734.1 → NP_001020905.1 transcriptional adapter 3

See identical proteins and their annotated locations for NP_001020905.1

Status: PROVISIONAL

Source sequence(s)

BC097414

UniProtKB/Swiss-Prot

Q4V8F5

UniProtKB/TrEMBL

A6IBQ8

Related

ENSRNOP00000077680.2, ENSRNOT00000112548.2

Conserved Domains (1) summary

pfam10198
Location:309 → 422

Ada3; Histone acetyltransferases subunit 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

148065859..148077347 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237040.3 → XP_006237102.1 transcriptional adapter 3 isoform X1

See identical proteins and their annotated locations for XP_006237102.1

UniProtKB/TrEMBL

A0A8I5Y660, A6IBQ8

Conserved Domains (1) summary

pfam10198
Location:317 → 430

Ada3; Histone acetyltransferases subunit 3
XM_039107832.2 → XP_038963760.1 transcriptional adapter 3 isoform X2

UniProtKB/Swiss-Prot

Q4V8F5

UniProtKB/TrEMBL

A6IBQ8

Conserved Domains (1) summary

pfam10198
Location:309 → 422

Ada3; Histone acetyltransferases subunit 3
XM_039107831.2 → XP_038963759.1 transcriptional adapter 3 isoform X1

UniProtKB/TrEMBL

A0A8I5Y660, A6IBQ8

Related

ENSRNOP00000011827.6, ENSRNOT00000011827.8

Conserved Domains (1) summary

pfam10198
Location:317 → 430

Ada3; Histone acetyltransferases subunit 3
XM_063286292.1 → XP_063142362.1 transcriptional adapter 3 isoform X4

UniProtKB/TrEMBL

A6IBQ8
XM_006237042.3 → XP_006237104.1 transcriptional adapter 3 isoform X2

See identical proteins and their annotated locations for XP_006237104.1

UniProtKB/Swiss-Prot

Q4V8F5

UniProtKB/TrEMBL

A6IBQ8

Conserved Domains (1) summary

pfam10198
Location:309 → 422

Ada3; Histone acetyltransferases subunit 3
XM_006237043.3 → XP_006237105.1 transcriptional adapter 3 isoform X3

UniProtKB/TrEMBL

A6IBQ8

Conserved Domains (1) summary

pfam10198
Location:268 → 368

Ada3; Histone acetyltransferases subunit 3
XM_063286291.1 → XP_063142361.1 transcriptional adapter 3 isoform X1

UniProtKB/TrEMBL

A0A8I5Y660, A6IBQ8
XM_039107833.2 → XP_038963761.1 transcriptional adapter 3 isoform X5