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Fgfr1op2 FGFR1 oncogene partner 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362463, updated on 27-Nov-2024

Summary

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Official Symbol
Fgfr1op2provided by RGD
Official Full Name
FGFR1 oncogene partner 2provided by RGD
Primary source
RGD:1303233
See related
EnsemblRapid:ENSRNOG00000001811 AllianceGenome:RGD:1303233
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wit3.0
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in response to wounding. Predicted to act upstream of or within wound healing. Located in cytoplasm. Orthologous to human FGFR1OP2 (FGFR1 oncogene partner 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 226.1), Heart (RPKM 196.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fgfr1op2 in Genome Data Viewer
Location:
4q44
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (181222298..181243318)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179491602..179512630)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (180887182..180908206)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486659 Neighboring gene integrator complex subunit 13 Neighboring gene E3 SUMO-protein ligase NSE2-like Neighboring gene transmembrane 7 superfamily member 3 Neighboring gene mediator complex subunit 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Oral fibroblast expression of wound-inducible transcript 3.0 (wit3.0) accelerates the collagen gel contraction in vitro. Sukotjo C, et al. J Biol Chem, 2003 Dec 19. PMID 14527947
  2. Molecular cloning of wound inducible transcript (wit 3.0) differentially expressed in edentulous oral mucosa undergoing tooth extraction wound-healing. Sukotjo C, et al. J Dent Res, 2002 Apr. PMID 12097305
  3. Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure. Lin A, et al. Am J Pathol, 2010 Jan. PMID 19959814, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGFR1OP2/wit3.0 may regulate cell motility and stimulate wound closure.
    Title: Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure.
  2. expressed by the fibroblasts associated with tooth extraction wound-healing (wit 3.0)
    Title: Molecular cloning of wound inducible transcript (wit 3.0) differentially expressed in edentulous oral mucosa undergoing tooth extraction wound-healing.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in response to wounding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FGFR1 oncogene partner 2 homolog
Names
Wit3.0_alpha
Wit3.0_beta
wound inducible transcript 3.0 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201421.2 → NP_958824.2  FGFR1 oncogene partner 2 homolog

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q5PPH1, Q6TA25, Q6TA26
    UniProtKB/TrEMBL
    A0A8L2QKW1, A6IN22
    Related
    ENSRNOP00000039568.4, ENSRNOT00000042270.5
    Conserved Domains (1) summary
    pfam05769
    Location:2 → 221
    SIKE; SIKE family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    181222298..181243318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237688.4 → XP_006237750.1  FGFR1 oncogene partner 2 homolog isoform X1

    See identical proteins and their annotated locations for XP_006237750.1

    UniProtKB/TrEMBL
    A0A8L2QKW1, A6IN23
    Related
    ENSRNOP00000002476.2, ENSRNOT00000002476.7
    Conserved Domains (1) summary
    pfam05769
    Location:2 → 183
    SIKE; SIKE family

  2. XM_008763402.3 → XP_008761624.1  FGFR1 oncogene partner 2 homolog isoform X2

    See identical proteins and their annotated locations for XP_008761624.1

    UniProtKB/TrEMBL
    A6IN24
    Conserved Domains (1) summary
    pfam05769
    Location:2 → 133
    DUF837; Protein of unknown function (DUF837)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TA25.2 GenPept UniProtKB/Swiss-Prot:Q6TA25

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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