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Tret1-1 Trehalose transporter 1-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36248, updated on 9-Dec-2024

Summary

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Official Symbol
Tret1-1provided by FlyBase
Official Full Name
Trehalose transporter 1-1provided by FlyBase
Primary source
FLYBASE:FBgn0050035
Locus tag
Dmel_CG30035
See related
AllianceGenome:FB:FBgn0050035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG30035; CG7797; CG7801; Dmel\CG30035; DmTret1-1; Tre T1; tret; Tret-1
Summary
Enables D-glucose transmembrane transporter activity and trehalose transmembrane transporter activity. Involved in D-glucose transmembrane transport and trehalose transport. Located in plasma membrane. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval fat body; glial cell; and larval central nervous system. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Tret1-1 in Genome Data Viewer
Location:
48B6-48B7; 2-64 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11665768..11674782)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7553273..7562287)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Regulator of cullins 2 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Methionine-CAT 1-2 Neighboring gene Trehalose transporter 1-2 Neighboring gene buffy Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plasticity of Carbohydrate Transport at the Blood-Brain Barrier. McMullen E, et al. Front Behav Neurosci, 2020. PMID 33551766, Free PMC Article
  2. Glucose and trehalose metabolism through the cyclic pentose phosphate pathway shapes pathogen resistance and host protection in Drosophila. Kazek M, et al. PLoS Biol, 2024 May. PMID 38713712, Free PMC Article
  3. The trehalose transporter 1 gene sequence is conserved in insects and encodes proteins with different kinetic properties involved in trehalose import into peripheral tissues. Kanamori Y, et al. Insect Biochem Mol Biol, 2010 Jan. PMID 20035867
  4. Feedforward Regulation of Glucose Metabolism by Steroid Hormones Drives a Developmental Transition in Drosophila. Nishimura T. Curr Biol, 2020 Sep 21. PMID 32679096
  5. Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis. Yoshida M, et al. Sci Rep, 2016 Jul 29. PMID 27469628, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sugar transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables trehalose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carbohydrate transport IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in lactose transport IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in maltose transport IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in sucrose transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in trehalose transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
trehalose transporter 1-1
Names
CG30035-PA
CG30035-PB
Tret1-1-PA
Tret1-1-PB
trehalose transporter
trehalose transporter 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11665768..11674782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136849.2 → NP_610693.1  trehalose transporter 1-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610693.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z8N1, A9ZSY5, Q6NQZ8, Q86P59
    Related
    FBpp0087178
    Conserved Domains (2) summary
    cd06174
    Location:401 → 822
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00879
    Location:382 → 833
    SP; MFS transporter, sugar porter (SP) family

  2. NM_165845.2 → NP_725068.1  trehalose transporter 1-1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725068.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z8N1
    Related
    FBpp0087179
    Conserved Domains (2) summary
    cd06174
    Location:33 → 454
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:31 → 467
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z8N1.1 A1Z8N1

Gene LinkOut

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