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Sh3d21 SH3 domain containing 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362598, updated on 4-Jan-2025

Summary

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Symbol
Sh3d21provided by RGD
Full Name
SH3 domain containing 21provided by RGD
Primary source
RGD:1305090
See related
EnsemblRapid:ENSRNOG00000024566 AllianceGenome:RGD:1305090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305090
Summary
Predicted to be involved in actin filament organization and cell migration. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human SH3D21 (SH3 domain containing 21). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 246.7), Lung (RPKM 43.0) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sh3d21 in Genome Data Viewer
Location:
5q36
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (143713718..143729073, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (138429180..138444540, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144161881..144178161, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 40 Neighboring gene uncharacterized LOC108351032 Neighboring gene eva-1 homolog B Neighboring gene thyroid hormone receptor associated protein 3 Neighboring gene uncharacterized LOC120103176

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 domain-containing protein 21
Names
SH3 domain-containing kinase-binding protein 1-like
SH3 domain-containing protein C1orf113 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162535.1 → NP_001156007.1  SH3 domain-containing protein 21

    Status: VALIDATED

    Source sequence(s)
    AW528754, BC162054
    UniProtKB/TrEMBL
    B1WC96, F6PUS4
    Conserved Domains (1) summary
    cd12142
    Location:70 → 123
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    143713718..143729073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764049.4 → XP_008762271.1  SH3 domain-containing protein 21 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJ24
    Related
    ENSRNOP00000092858.2, ENSRNOT00000106147.2
    Conserved Domains (3) summary
    cd11874
    Location:156 → 208
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd12142
    Location:255 → 308
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
    cl17036
    Location:72 → 125
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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