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Ifnlr1 interferon, lambda receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362628, updated on 9-Dec-2024

Summary

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Official Symbol
Ifnlr1provided by RGD
Official Full Name
interferon, lambda receptor 1provided by RGD
Primary source
RGD:1562689
See related
EnsemblRapid:ENSRNOG00000033984 AllianceGenome:RGD:1562689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Il28ra; RGD1562689
Summary
Predicted to enable cytokine receptor activity. Predicted to be involved in several processes, including mucosal immune response; positive regulation of cellular respiration; and regulation of defense response to virus by host. Predicted to act upstream of or within defense response to virus. Predicted to be part of interleukin-28 receptor complex. Predicted to be active in plasma membrane. Orthologous to human IFNLR1 (interferon lambda receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 21.6), Heart (RPKM 18.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ifnlr1 in Genome Data Viewer
Location:
5q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153203597..153225911)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (147919547..147942328)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154037243..154058862)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700029M20 gene like Neighboring gene uncharacterized LOC134479040 Neighboring gene interleukin 22 receptor subunit alpha 1 Neighboring gene myomesin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. IFN-lambda determines the intestinal epithelial antiviral host defense. Pott J, et al. Proc Natl Acad Sci U S A, 2011 May 10. PMID 21518880, Free PMC Article
  2. IL-28, IL-29 and their class II cytokine receptor IL-28R. Sheppard P, et al. Nat Immunol, 2003 Jan. PMID 12469119
  3. An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. Ank N, et al. J Immunol, 2008 Feb 15. PMID 18250457
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in mucosal immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cellular respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of interleukin-28 receptor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon lambda receptor 1
Names
interleukin 28 receptor alpha
interleukin-28 receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191868.2 → NP_001178797.1  interferon lambda receptor 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D3ZB58
    Related
    ENSRNOP00000048303.4, ENSRNOT00000049459.7
    Conserved Domains (1) summary
    pfam01108
    Location:20 → 109
    Tissue_fac; Tissue factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    153203597..153225911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288069.1 → XP_063144139.1  interferon lambda receptor 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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