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Sln Silnoon [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36263, updated on 4-Jan-2025

Summary

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Official Symbol
Slnprovided by FlyBase
Official Full Name
Silnoonprovided by FlyBase
Primary source
FLYBASE:FBgn0033657
Locus tag
Dmel_CG8271
See related
AllianceGenome:FB:FBgn0033657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8271; Dmel\CG8271
Summary
Enables monocarboxylic acid transmembrane transporter activity. Involved in import across plasma membrane; monocarboxylic acid transport; and neuron cellular homeostasis. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in adult head; eye disc; organism; and wing disc. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to several human genes including SLC16A12 (solute carrier family 16 member 12) and SLC16A5 (solute carrier family 16 member 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Sln in Genome Data Viewer
Location:
48C4-48C5; 2-65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11845324..11852324)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7732829..7739829)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44304 Neighboring gene site-2 protease Neighboring gene uncharacterized protein Neighboring gene Megator Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster. Jang C, et al. J Cell Biol, 2008 Oct 6. PMID 18838551, Free PMC Article
  2. Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster. Matthews KA, et al. Genetics, 2009 Jan. PMID 19015545, Free PMC Article
  3. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Silva B, et al. Nat Metab, 2022 Feb. PMID 35177854, Free PMC Article
  4. A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation. Gándara L, et al. Sci Rep, 2019 Dec 27. PMID 31882718, Free PMC Article
  5. Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila. Rabah Y, et al. Nat Metab, 2023 Nov. PMID 37932430, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monocarboxylic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monocarboxylic acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monocarboxylic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monocarboxylic acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
silnoon
Names
CG8271-PA
Sln-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11845324..11852324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136862.2 → NP_610706.1  silnoon [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610706.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U154
    Related
    FBpp0087139
    Conserved Domains (2) summary
    cd06174
    Location:656 → 827
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:658 → 847
    MFS_1; Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U154 Q5U154

Gene LinkOut

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