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Cda cytidine deaminase [ Rattus norvegicus (Norway rat) ]

Gene ID: 362638, updated on 27-Nov-2024

Summary

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Symbol
Cdaprovided by RGD
Full Name
cytidine deaminaseprovided by RGD
Primary source
RGD:1311101
See related
EnsemblRapid:ENSRNOG00000015677 AllianceGenome:RGD:1311101
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables cytidine deaminase activity. Involved in cellular response to external biotic stimulus; cytidine deamination; and response to cycloheximide. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 13.5), Heart (RPKM 11.9) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cda in Genome Data Viewer
Location:
5q36
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155839929..155866541, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (150556615..150583231, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156703579..156734541, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Neighboring gene PTEN induced kinase 1 Neighboring gene uncharacterized LOC134487022 Neighboring gene family with sequence similarity 43, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Pyrimidine nucleotide synthesis in rat liver after the administration of cycloheximide. Seifert J, et al. Toxicology, 1978 May. PMID 675715
  2. Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. Sugiyama E, et al. J Clin Oncol, 2007 Jan 1. PMID 17194903
  3. Structure of human cytidine deaminase bound to a potent inhibitor. Chung SJ, et al. J Med Chem, 2005 Feb 10. PMID 15689149
  4. Growth inhibition of granulocyte-macrophage colony-forming cells by human cytidine deaminase requires the catalytic function of the protein. Gran C, et al. Blood, 1998 Jun 1. PMID 9596658
  5. Development of multidrug resistance due to multiple factors including P-glycoprotein overexpression under K-selection after MYC and HRAS oncogene activation. Nakamura Y, et al. Int J Cancer, 2006 May 15. PMID 16353156

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytidine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytidine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytidine deaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in UMP salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to external biotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cytidine deamination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytidine deamination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytidine deamination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cycloheximide IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytidine deaminase
NP_001102158.1
XP_038966350.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108688.1 → NP_001102158.1  cytidine deaminase

    See identical proteins and their annotated locations for NP_001102158.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A6ITH4, D4AC20
    Related
    ENSRNOP00000021036.4, ENSRNOT00000021036.6
    Conserved Domains (1) summary
    TIGR01354
    Location:16 → 142
    cyt_deam_tetra; cytidine deaminase, homotetrameric

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    155839929..155866541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110422.2 → XP_038966350.1  cytidine deaminase isoform X1

    Conserved Domains (1) summary
    TIGR01354
    Location:11 → 101
    cyt_deam_tetra; cytidine deaminase, homotetrameric
Nucleotide Protein Strain
Heading Accession and Version

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