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Sh3yl1 SH3 and SYLF domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362724, updated on 27-Nov-2024

Summary

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Official Symbol
Sh3yl1provided by RGD
Official Full Name
SH3 and SYLF domain containing 1provided by RGD
Primary source
RGD:1306440
See related
EnsemblRapid:ENSRNOG00000005522 AllianceGenome:RGD:1306440
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatase binding activity and phosphatidylinositol binding activity. Predicted to be involved in regulation of ruffle assembly. Predicted to act upstream of or within phosphatidylinositol biosynthetic process. Predicted to be active in ruffle membrane. Orthologous to human SH3YL1 (SH3 and SYLF domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 83.8), Spleen (RPKM 60.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sh3yl1 in Genome Data Viewer
Location:
6q16
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (53250036..53293406)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (47522098..47565858)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (49851778..49895502)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ALK and LTK ligand 2 Neighboring gene uncharacterized LOC134479359 Neighboring gene acid phosphatase 1 Neighboring gene HIRA interacting protein 3, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. Hasegawa J, et al. J Cell Biol, 2011 May 30. PMID 21624956, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 domain-containing YSC84-like protein 1
Names
SH3 domain containing, Ysc84-like 1
Sh3 domain YSC-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108705.2 → NP_001102175.1  SH3 domain-containing YSC84-like protein 1

    See identical proteins and their annotated locations for NP_001102175.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158742
    UniProtKB/Swiss-Prot
    B0BNA1
    UniProtKB/TrEMBL
    A0A8I6GLW3, A6HB38
    Related
    ENSRNOP00000097062.2, ENSRNOT00000114306.2
    Conserved Domains (2) summary
    cd11525
    Location:11 → 209
    SYLF_SH3YL1_like; The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins
    cd11841
    Location:285 → 338
    SH3_SH3YL1_like; Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    53250036..53293406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239970.5 → XP_006240032.1  SH3 domain-containing YSC84-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6B697, A0A8I6GLW3
    Related
    ENSRNOP00000097804.1, ENSRNOT00000104926.2
    Conserved Domains (2) summary
    cd11525
    Location:11 → 209
    SYLF_SH3YL1_like; The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins
    cd11841
    Location:295 → 348
    SH3_SH3YL1_like; Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein

  2. XM_063262076.1 → XP_063118146.1  SH3 domain-containing YSC84-like protein 1 isoform X3

  3. XM_063262077.1 → XP_063118147.1  SH3 domain-containing YSC84-like protein 1 isoform X3

  4. XM_063262075.1 → XP_063118145.1  SH3 domain-containing YSC84-like protein 1 isoform X2

RNA

  1. XR_005505541.2 RNA Sequence

  2. XR_010052117.1 RNA Sequence

  3. XR_010052118.1 RNA Sequence

  4. XR_005505542.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0BNA1.1 GenPept UniProtKB/Swiss-Prot:B0BNA1

Gene LinkOut

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