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Heatr5a HEAT repeat containing 5A [ Rattus norvegicus (Norway rat) ]

Gene ID: 362737, updated on 27-Nov-2024

Summary

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Official Symbol
Heatr5aprovided by RGD
Official Full Name
HEAT repeat containing 5Aprovided by RGD
Primary source
RGD:1561116
See related
EnsemblRapid:ENSRNOG00000006483 AllianceGenome:RGD:1561116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561116
Summary
Predicted to be involved in endocytosis; protein localization; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Predicted to be active in endocytic vesicle. Orthologous to human HEATR5A (HEAT repeat containing 5A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 98.8), Lung (RPKM 87.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Heatr5a in Genome Data Viewer
Location:
6q23
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (75057226..75155207, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69321869..69419861, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72648654..72750202, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103536 Neighboring gene HECT domain E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC134479181 Neighboring gene uncharacterized LOC134479124 Neighboring gene G protein-coupled receptor 33, pseudogene 1 Neighboring gene D-aminoacyl-tRNA deacylase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
HEAT repeat-containing protein 5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419842.1 → NP_001406771.1  HEAT repeat-containing protein 5A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    75057226..75155207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262110.1 → XP_063118180.1  HEAT repeat-containing protein 5A isoform X8

  2. XM_063262109.1 → XP_063118179.1  HEAT repeat-containing protein 5A isoform X6

  3. XM_063262108.1 → XP_063118178.1  HEAT repeat-containing protein 5A isoform X7

  4. XM_039078140.1 → XP_038934068.1  HEAT repeat-containing protein 5A isoform X1

    UniProtKB/TrEMBL
    A0A8I6AF96
    Conserved Domains (1) summary
    sd00044
    Location:97 → 121
    HEAT; HEAT repeat [structural motif]

  5. XM_039078149.2 → XP_038934077.1  HEAT repeat-containing protein 5A isoform X6

    UniProtKB/TrEMBL
    A0A8I6AF96
    Related
    ENSRNOP00000091464.1, ENSRNOT00000119095.2
    Conserved Domains (1) summary
    sd00044
    Location:97 → 121
    HEAT; HEAT repeat [structural motif]

  6. XM_039078146.2 → XP_038934074.1  HEAT repeat-containing protein 5A isoform X4

    UniProtKB/TrEMBL
    A0A8I6AF96
    Conserved Domains (1) summary
    sd00044
    Location:97 → 121
    HEAT; HEAT repeat [structural motif]

  7. XM_039078144.2 → XP_038934072.1  HEAT repeat-containing protein 5A isoform X2

    UniProtKB/TrEMBL
    A0A8I6AF96
    Related
    ENSRNOP00000101861.1, ENSRNOT00000134452.1
    Conserved Domains (1) summary
    sd00044
    Location:97 → 121
    HEAT; HEAT repeat [structural motif]

  8. XM_039078147.2 → XP_038934075.1  HEAT repeat-containing protein 5A isoform X5

    UniProtKB/TrEMBL
    A0A8I6AF96
    Related
    ENSRNOP00000035775.5, ENSRNOT00000035309.6
    Conserved Domains (1) summary
    sd00044
    Location:97 → 121
    HEAT; HEAT repeat [structural motif]

  9. XM_039078145.2 → XP_038934073.1  HEAT repeat-containing protein 5A isoform X3

    UniProtKB/TrEMBL
    A0A8I6AF96
    Conserved Domains (1) summary
    sd00044
    Location:97 → 121
    HEAT; HEAT repeat [structural motif]

  10. XM_039078139.2 → XP_038934067.1  HEAT repeat-containing protein 5A isoform X1

    UniProtKB/TrEMBL
    A0A8I6AF96
    Conserved Domains (1) summary
    sd00044
    Location:97 → 121
    HEAT; HEAT repeat [structural motif]

  11. XM_039078141.2 → XP_038934069.1  HEAT repeat-containing protein 5A isoform X1

    UniProtKB/TrEMBL
    A0A8I6AF96
    Conserved Domains (1) summary
    sd00044
    Location:97 → 121
    HEAT; HEAT repeat [structural motif]

  12. XM_039078142.2 → XP_038934070.1  HEAT repeat-containing protein 5A isoform X1

    UniProtKB/TrEMBL
    A0A8I6AF96
    Conserved Domains (1) summary
    sd00044
    Location:97 → 121
    HEAT; HEAT repeat [structural motif]

  13. XM_039078143.2 → XP_038934071.1  HEAT repeat-containing protein 5A isoform X1

    UniProtKB/TrEMBL
    A0A8I6AF96
    Conserved Domains (1) summary
    sd00044
    Location:97 → 121
    HEAT; HEAT repeat [structural motif]

  14. XM_063262111.1 → XP_063118181.1  HEAT repeat-containing protein 5A isoform X9

  15. XM_039078151.2 → XP_038934079.1  HEAT repeat-containing protein 5A isoform X10

    UniProtKB/TrEMBL
    A0A8I6AF96
    Conserved Domains (1) summary
    sd00044
    Location:97 → 121
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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