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Tmx1 thioredoxin-related transmembrane protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362751, updated on 4-Jan-2025

Summary

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Official Symbol
Tmx1provided by RGD
Official Full Name
thioredoxin-related transmembrane protein 1provided by RGD
Primary source
RGD:1308455
See related
EnsemblRapid:ENSRNOG00000057934 AllianceGenome:RGD:1308455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Txndc1
Summary
Predicted to enable enzyme inhibitor activity; protein disulfide isomerase activity; and protein-disulfide reductase activity. Predicted to be involved in several processes, including negative regulation of platelet aggregation; negative regulation of triglyceride biosynthetic process; and positive regulation of ERAD pathway. Predicted to be active in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to human TMX1 (thioredoxin related transmembrane protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 285.3), Brain (RPKM 251.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmx1 in Genome Data Viewer
Location:
6q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (94696699..94707751)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88960691..88971744)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (92864123..92875141)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549102 Neighboring gene sorting nexin 7, pseudogene 1 Neighboring gene uncharacterized LOC102551922 Neighboring gene uncharacterized LOC120103546 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC102552060

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Reductive activation of type 2 ribosome-inactivating proteins is promoted by transmembrane thioredoxin-related protein. Pasetto M, et al. J Biol Chem, 2012 Mar 2. PMID 22228764, Free PMC Article
  2. Identification of a novel thioredoxin-related transmembrane protein. Matsuo Y, et al. J Biol Chem, 2001 Mar 30. PMID 11152479
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables disulfide oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables disulfide oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein disulfide isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
thioredoxin-related transmembrane protein 1
Names
thioredoxin domain containing 1
NP_001019971.1
XP_006240240.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024800.2 → NP_001019971.1  thioredoxin-related transmembrane protein 1 precursor

    See identical proteins and their annotated locations for NP_001019971.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A0G2K1D9, Q52KJ9
    Related
    ENSRNOP00000081790.1, ENSRNOT00000100740.2
    Conserved Domains (1) summary
    cd02994
    Location:29 → 129
    PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    94696699..94707751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240178.5 → XP_006240240.1  thioredoxin-related transmembrane protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A1Z5
    Related
    ENSRNOP00000071802.3, ENSRNOT00000087540.3
    Conserved Domains (1) summary
    cl00388
    Location:70 → 149
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein Strain
Heading Accession and Version

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