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Dcaf4 DDB1 and CUL4 associated factor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362762, updated on 4-Jan-2025

Summary

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Official Symbol
Dcaf4provided by RGD
Official Full Name
DDB1 and CUL4 associated factor 4provided by RGD
Primary source
RGD:1306241
See related
EnsemblRapid:ENSRNOG00000008399 AllianceGenome:RGD:1306241
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wdr21
Summary
Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to several human genes including DCAF4 (DDB1 and CUL4 associated factor 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 63.0), Adrenal (RPKM 53.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dcaf4 in Genome Data Viewer
Location:
6q31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (108885970..108912116)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103154847..103180992)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107001763..107027466)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 6 Neighboring gene uncharacterized LOC120093217 Neighboring gene double PHD fingers 3 Neighboring gene uncharacterized LOC134479225 Neighboring gene uncharacterized LOC134479227 Neighboring gene uncharacterized LOC134479226 Neighboring gene uncharacterized LOC102547293 Neighboring gene zinc finger FYVE-type containing 1 Neighboring gene RNA binding motif protein 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 4
Names
WD repeat domain 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108716.1 → NP_001102186.1  DDB1- and CUL4-associated factor 4

    See identical proteins and their annotated locations for NP_001102186.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473982
    UniProtKB/TrEMBL
    A6JDQ0
    Conserved Domains (3) summary
    COG2319
    Location:301 → 470
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:285 → 323
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:313 → 470
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    108885970..108912116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240347.5 → XP_006240409.1  DDB1- and CUL4-associated factor 4 isoform X1

    UniProtKB/TrEMBL
    D4A7F7
    Related
    ENSRNOP00000011378.6, ENSRNOT00000011378.8
    Conserved Domains (3) summary
    COG2319
    Location:302 → 471
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:286 → 324
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:314 → 471
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_063262119.1 → XP_063118189.1  DDB1- and CUL4-associated factor 4 isoform X2

  3. XM_039112513.1 → XP_038968441.1  DDB1- and CUL4-associated factor 4 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:71 → 109
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:96 → 256
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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