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Ttc7b tetratricopeptide repeat domain 7B [ Rattus norvegicus (Norway rat) ]

Gene ID: 362768, updated on 9-Dec-2024

Summary

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Official Symbol
Ttc7bprovided by RGD
Official Full Name
tetratricopeptide repeat domain 7Bprovided by RGD
Primary source
RGD:1305920
See related
EnsemblRapid:ENSRNOG00000027300 AllianceGenome:RGD:1305920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human TTC7B (tetratricopeptide repeat domain 7B). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 211.9), Brain (RPKM 209.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ttc7b in Genome Data Viewer
Location:
6q32
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (125317011..125528843, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (119587389..119799167, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (124316444..124528058, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479248 Neighboring gene calmodulin 1 Neighboring gene ribosomal protein S6 kinase A5 Neighboring gene U6 spliceosomal RNA Neighboring gene polycomb group ring finger 5 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Baskin JM, et al. Nat Cell Biol, 2016 Jan. PMID 26571211, Free PMC Article
  2. PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. Nakatsu F, et al. J Cell Biol, 2012 Dec 10. PMID 23229899, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108719.3 → NP_001102189.2  tetratricopeptide repeat protein 7B isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A0G2JXJ6
    Related
    ENSRNOP00000070298.3, ENSRNOT00000080950.3

  2. NM_001401371.1 → NP_001388300.1  tetratricopeptide repeat protein 7B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6A7F1
    Related
    ENSRNOP00000089503.1, ENSRNOT00000108767.2

  3. NM_001401373.1 → NP_001388302.1  tetratricopeptide repeat protein 7B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AFJ5
    Related
    ENSRNOP00000091624.1, ENSRNOT00000099229.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    125317011..125528843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112527.2 → XP_038968455.1  tetratricopeptide repeat protein 7B isoform X3

    Conserved Domains (4) summary
    TIGR00990
    Location:686 → 859
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    TIGR02917
    Location:343 → 851
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:431 → 459
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:747 → 775
    TPR; TPR repeat [structural motif]

  2. XM_063262123.1 → XP_063118193.1  tetratricopeptide repeat protein 7B isoform X2

  3. XM_039112520.2 → XP_038968448.1  tetratricopeptide repeat protein 7B isoform X1

    Conserved Domains (4) summary
    COG0457
    Location:365 → 619
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR00990
    Location:757 → 930
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00008
    Location:431 → 459
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:818 → 846
    TPR; TPR repeat [structural motif]

  4. XM_063262125.1 → XP_063118195.1  tetratricopeptide repeat protein 7B isoform X5

  5. XM_063262126.1 → XP_063118196.1  tetratricopeptide repeat protein 7B isoform X6

  6. XM_063262124.1 → XP_063118194.1  tetratricopeptide repeat protein 7B isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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