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Serpina11 serpin family A member 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362774, updated on 27-Nov-2024

Summary

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Official Symbol
Serpina11provided by RGD
Official Full Name
serpin family A member 11provided by RGD
Primary source
RGD:1359239
See related
EnsemblRapid:ENSRNOG00000011141 AllianceGenome:RGD:1359239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab1-046
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Orthologous to human SERPINA11 (serpin family A member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 576.8) See more
Orthologs
human all
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Genomic context

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See Serpina11 in Genome Data Viewer
Location:
6q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (128668030..128677476, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (122903246..122912695, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127647180..127656603, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene serpin family A member 1 Neighboring gene uncharacterized LOC134479253 Neighboring gene serpin family A member 9 Neighboring gene uncharacterized LOC108351294 Neighboring gene serpin family A member 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Hida K, et al. Proc Natl Acad Sci U S A, 2005 Jul 26. PMID 16030142, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124917

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serpin A11
Names
liver regeneration-related protein LRRG023
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
serpin peptidase inhibitor, clade A, member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008776.3 → NP_001008776.1  serpin A11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001008776.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AH22, A6JEP8
    Related
    ENSRNOP00000041705.3, ENSRNOT00000047324.8
    Conserved Domains (1) summary
    cd02056
    Location:53 → 456
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

  2. NM_001166352.2 → NP_001159824.1  serpin A11 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001159824.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q2M2R9, Q7TPA5
    UniProtKB/TrEMBL
    A0A8I6AH22, A6JEP7
    Related
    ENSRNOP00000015516.3, ENSRNOT00000015516.6
    Conserved Domains (1) summary
    cd02056
    Location:53 → 416
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    128668030..128677476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240481.4 → XP_006240543.1  serpin A11 isoform X1

    Conserved Domains (1) summary
    cd02056
    Location:53 → 456
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPA5.2 GenPept UniProtKB/Swiss-Prot:Q7TPA5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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