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Pwwp3a PWWP domain containing 3A, DNA repair factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 362838, updated on 2-Nov-2024

Summary

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Official Symbol
Pwwp3aprovided by RGD
Official Full Name
PWWP domain containing 3A, DNA repair factorprovided by RGD
Primary source
RGD:1308340
See related
EnsemblRapid:ENSRNOG00000024549 AllianceGenome:RGD:1308340
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mum1
Summary
Predicted to enable nucleosome binding activity. Predicted to be involved in DNA repair and chromatin organization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PWWP3A (PWWP domain containing 3A, DNA repair factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 226.5), Thymus (RPKM 84.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pwwp3a in Genome Data Viewer
Location:
7q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10115865..10132696, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9465180..9482053, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12331288..12348263, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7 Neighboring gene transfer RNA asparagine (anticodon GUU) 8 Neighboring gene transfer RNA phenylalanine (anticodon GAA) 3 Neighboring gene large ribosomal subunit protein eL33-like Neighboring gene ephrin A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Huen MS, et al. Mol Cell, 2010 Mar 26. PMID 20347427, Free PMC Article
  2. Double-strand break repair: 53BP1 comes into focus. Panier S, et al. Nat Rev Mol Cell Biol, 2014 Jan. PMID 24326623
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
PWWP domain-containing DNA repair factor 3A
Names
MUM-1
PWWP domain-containing protein MUM1
melanoma associated antigen (mutated) 1
melanoma ubiquitous mutated protein
mutated melanoma-associated antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108736.2 → NP_001102206.2  PWWP domain-containing DNA repair factor 3A

    Status: PROVISIONAL

    Source sequence(s)
    CB784307, CK597826, CK603499, CK839769, CO383806, CV126168
    UniProtKB/TrEMBL
    A0A8I5ZQH5, A0A8L2QRY6
    Conserved Domains (2) summary
    cd06080
    Location:396 → 475
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
    pfam03546
    Location:73 → 360
    Treacle; Treacher Collins syndrome protein Treacle

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10115865..10132696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240973.5 → XP_006241035.1  PWWP domain-containing DNA repair factor 3A isoform X1

    See identical proteins and their annotated locations for XP_006241035.1

    UniProtKB/Swiss-Prot
    B1H224
    UniProtKB/TrEMBL
    A0A8I5ZQH5
    Related
    ENSRNOP00000057438.4, ENSRNOT00000060708.4
    Conserved Domains (1) summary
    cd06080
    Location:397 → 487
    PWWP_MUM1-like; PWWP domain found in mutated melanoma-associated antigen 1 (MUM-1) and similar proteins

  2. XM_039079406.2 → XP_038935334.1  PWWP domain-containing DNA repair factor 3A isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQH5, A0A8L2QRY6
    Conserved Domains (2) summary
    cd06080
    Location:396 → 475
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
    pfam03546
    Location:73 → 360
    Treacle; Treacher Collins syndrome protein Treacle

  3. XM_006240974.5 → XP_006241036.1  PWWP domain-containing DNA repair factor 3A isoform X1

    See identical proteins and their annotated locations for XP_006241036.1

    UniProtKB/Swiss-Prot
    B1H224
    UniProtKB/TrEMBL
    A0A8I5ZQH5
    Conserved Domains (1) summary
    cd06080
    Location:397 → 487
    PWWP_MUM1-like; PWWP domain found in mutated melanoma-associated antigen 1 (MUM-1) and similar proteins

  4. XM_063263746.1 → XP_063119816.1  PWWP domain-containing DNA repair factor 3A isoform X2

    UniProtKB/TrEMBL
    A0A8L2QRY6

  5. XM_006240975.5 → XP_006241037.1  PWWP domain-containing DNA repair factor 3A isoform X1

    See identical proteins and their annotated locations for XP_006241037.1

    UniProtKB/Swiss-Prot
    B1H224
    UniProtKB/TrEMBL
    A0A8I5ZQH5
    Conserved Domains (1) summary
    cd06080
    Location:397 → 487
    PWWP_MUM1-like; PWWP domain found in mutated melanoma-associated antigen 1 (MUM-1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1H224.1 GenPept UniProtKB/Swiss-Prot:B1H224

Gene LinkOut

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