otk2 off-track2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: otk2provided by FlyBase
Official Full Name: off-track2provided by FlyBase
Primary source: FLYBASE:FBgn0267728
Locus tag: Dmel_CG8964
See related: AllianceGenome:FB:FBgn0267728
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8964; CT25760; Dmel\CG8964; l(2)SH1639; l(2)SH2 1639; otK2
Summary: Enables Wnt-protein binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in imaginal disc-derived female genitalia morphogenesis; imaginal disc-derived male genitalia morphogenesis; and internal genitalia morphogenesis. Predicted to be located in membrane. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including adult fat body; adult head; embryonic/larval gut; imaginal disc; and larval brain. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12023146..12025272, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7910651..7912777, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in imaginal disc-derived female genitalia morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in internal genitalia morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain