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Mier2 MIER family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362841, updated on 27-Nov-2024

Summary

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Official Symbol
Mier2provided by RGD
Official Full Name
MIER family member 2provided by RGD
Primary source
RGD:1307278
See related
EnsemblRapid:ENSRNOG00000000175 AllianceGenome:RGD:1307278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307278
Summary
Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to contribute to histone deacetylase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Orthologous to human MIER2 (MIER family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 48.7), Spleen (RPKM 25.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mier2 in Genome Data Viewer
Location:
7q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10804238..10819979)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (10153501..10169381)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (13039759..13055632)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479817 Neighboring gene sperm microtubule associated protein 2 Neighboring gene phospholipid phosphatase 2 Neighboring gene uncharacterized LOC120093534

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. Derwish R, et al. PLoS One, 2017. PMID 28046085, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mesoderm induction early response protein 2
Names
mesoderm induction early response 1, family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394321.2 → NP_001381250.1  mesoderm induction early response protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6K904, D3ZR39
    Conserved Domains (2) summary
    cd11661
    Location:301 → 345
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:196 → 246
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10804238..10819979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594913.3 → XP_017450402.1  mesoderm induction early response protein 2 isoform X4

    UniProtKB/TrEMBL
    A6K903, D3ZR39
    Conserved Domains (3) summary
    smart00717
    Location:324 → 370
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:325 → 369
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:220 → 270
    ELM2; ELM2 domain

  2. XM_039079407.2 → XP_038935335.2  mesoderm induction early response protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JT20

  3. XM_039079408.2 → XP_038935336.2  mesoderm induction early response protein 2 isoform X2

    Related
    ENSRNOP00000068538.3, ENSRNOT00000090048.3

  4. XM_063263747.1 → XP_063119817.1  mesoderm induction early response protein 2 isoform X5

  5. XM_017594912.3 → XP_017450401.1  mesoderm induction early response protein 2 isoform X3

  6. XM_063263749.1 → XP_063119819.1  mesoderm induction early response protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JT20

  7. XM_039079411.2 → XP_038935339.1  mesoderm induction early response protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JT20, D3ZR39
    Conserved Domains (2) summary
    cd11661
    Location:289 → 333
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:184 → 234
    ELM2; ELM2 domain

  8. XM_063263748.1 → XP_063119818.1  mesoderm induction early response protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JT20

  9. XM_039079409.2 → XP_038935337.1  mesoderm induction early response protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JT20, D3ZR39
    Conserved Domains (2) summary
    cd11661
    Location:289 → 333
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:184 → 234
    ELM2; ELM2 domain

  10. XM_039079410.2 → XP_038935338.1  mesoderm induction early response protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JT20, D3ZR39
    Conserved Domains (2) summary
    cd11661
    Location:289 → 333
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:184 → 234
    ELM2; ELM2 domain

  11. XM_017594914.3 → XP_017450403.1  mesoderm induction early response protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JT20, D3ZR39
    Conserved Domains (2) summary
    cd11661
    Location:289 → 333
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:184 → 234
    ELM2; ELM2 domain

  12. XM_017594915.3 → XP_017450404.1  mesoderm induction early response protein 2 isoform X2

    UniProtKB/TrEMBL
    D3ZR39

  13. XM_039079412.2 → XP_038935340.1  mesoderm induction early response protein 2 isoform X6

    UniProtKB/TrEMBL
    A6K907, D3ZR39
    Conserved Domains (2) summary
    cd11661
    Location:241 → 285
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:136 → 186
    ELM2; ELM2 domain

RNA

  1. XR_010052993.1 RNA Sequence

  2. XR_010052994.1 RNA Sequence

  3. XR_010052995.1 RNA Sequence

  4. XR_010052996.1 RNA Sequence

  5. XR_010052998.1 RNA Sequence

  6. XR_010052997.1 RNA Sequence

  7. XR_010053000.1 RNA Sequence

  8. XR_010052999.1 RNA Sequence

  9. XR_010053001.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108737.1: Suppressed sequence

    Description
    NM_001108737.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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