Polr3B RNA polymerase III subunit B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Polr3Bprovided by FlyBase
Official Full Name: RNA polymerase III subunit Bprovided by FlyBase
Primary source: FLYBASE:FBgn0004463
Locus tag: Dmel_CG8344
See related: AllianceGenome:FB:FBgn0004463
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: C128; CG8344; Dmel\CG8344; DmRP128; RET1; RP128; RpIII128
Summary: Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III. Predicted to be part of RNA polymerase III complex. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and hypomyelinating leukodystrophy 8. Orthologous to human POLR3B (RNA polymerase III subunit B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12039041..12042623)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7926546..7930128)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Thus, stimulation of Pol III is a key downstream effector of TOR in the control of cellular and systemic growth.
Title: Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila.
conserved sequences within the spacer of pol gamma may position the substrate with respect to the enzyme catalytic domains
Title: Mutations in the spacer region of Drosophila mitochondrial DNA polymerase affect DNA binding, processivity, and the balance between Pol and Exo function.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase III activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribonucleoside binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in tRNA transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	ISS Inferred from Sequence or Structural Similarity more info