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St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362924, updated on 27-Nov-2024

Summary

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Official Symbol
St3gal1provided by RGD
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1provided by RGD
Primary source
RGD:1309373
See related
EnsemblRapid:ENSRNOG00000008209 AllianceGenome:RGD:1309373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat4a
Summary
Predicted to enable beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Predicted to be involved in several processes, including ganglioside biosynthetic process via lactosylceramide; memory B cell differentiation; and negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in Golgi medial cisterna membrane; Golgi trans cisterna membrane; and trans-Golgi network membrane. Predicted to be active in membrane. Orthologous to human ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 236.3), Spleen (RPKM 204.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St3gal1 in Genome Data Viewer
Location:
7q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (100734300..100802443, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (98845270..98913409, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (107895045..107963158, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene N-myc downstream regulated 1 Neighboring gene uncharacterized LOC102550354 Neighboring gene uncharacterized LOC134479742 Neighboring gene MLV-related proviral Env polyprotein-like Neighboring gene uncharacterized LOC134479743

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural insight into mammalian sialyltransferases. Rao FV, et al. Nat Struct Mol Biol, 2009 Nov. PMID 19820709
  2. Structure-function analysis of the human sialyltransferase ST3Gal I: role of n-glycosylation and a novel conserved sialylmotif. Jeanneau C, et al. J Biol Chem, 2004 Apr 2. PMID 14722111
  3. Molecular cloning and expression of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase from mouse brain. Lee YC, et al. Eur J Biochem, 1993 Sep 1. PMID 8375377
  4. Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation. Martin LT, et al. J Biol Chem, 2002 Sep 6. PMID 12068010
  5. Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Kono M, et al. Glycobiology, 1997 Jun. PMID 9184827

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-acetylneuraminate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide ISO
Inferred from Sequence Orthology
more info
  
involved_in memory B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sialylation ISO
Inferred from Sequence Orthology
more info
  
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sialylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi medial cisterna membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi trans cisterna membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Names
sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)
sialyltransferase ST3Gal-I
NP_001013237.2
XP_006241772.1
XP_008763735.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013219.2 → NP_001013237.2  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    100734300..100802443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765513.4 → XP_008763735.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_008763735.1

    UniProtKB/TrEMBL
    Q6H8N0
    Related
    ENSRNOP00000076083.3, ENSRNOT00000093353.3
    Conserved Domains (1) summary
    pfam00777
    Location:83 → 338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_006241710.4 → XP_006241772.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006241772.1

    UniProtKB/TrEMBL
    Q6H8N0
    Conserved Domains (1) summary
    pfam00777
    Location:83 → 338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version

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