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Zfat zinc finger and AT hook domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 362925, updated on 4-Jan-2025

Summary

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Official Symbol
Zfatprovided by RGD
Official Full Name
zinc finger and AT hook domain containingprovided by RGD
Primary source
RGD:1310886
See related
EnsemblRapid:ENSRNOG00000025140 AllianceGenome:RGD:1310886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfat1; Zfp406
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within hematopoietic progenitor cell differentiation and spongiotrophoblast layer development. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in autoimmune thyroiditis. Orthologous to human ZFAT (zinc finger and AT-hook domain containing). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 53.3), Thymus (RPKM 32.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfat in Genome Data Viewer
Location:
7q34
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (101775916..101951135, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (99886954..100054288, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (109037777..109207511, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein K, pseudogene 1 Neighboring gene NOP2 nucleolar protein, pseudogene 3 Neighboring gene uncharacterized LOC120093680 Neighboring gene uncharacterized LOC102551574 Neighboring gene microRNA 30b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands. Tsunoda T, et al. Proc Natl Acad Sci U S A, 2010 Aug 10. PMID 20660741, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spongiotrophoblast layer development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein ZFAT
Names
ZFAT zinc finger 1
zinc finger protein 406

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134957.2 → NP_001128429.1  zinc finger protein ZFAT isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D4A2U0
    Conserved Domains (3) summary
    sd00017
    Location:266 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:264 → 286
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:278 → 300
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001414958.1 → NP_001401887.1  zinc finger protein ZFAT isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    Related
    ENSRNOP00000059224.3, ENSRNOT00000068291.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    101775916..101951135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241713.5 → XP_006241775.1  zinc finger protein ZFAT isoform X1

    UniProtKB/TrEMBL
    D4A2U0
    Conserved Domains (3) summary
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:270 → 292
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:284 → 306
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017594961.3 → XP_017450450.1  zinc finger protein ZFAT isoform X2

    UniProtKB/TrEMBL
    A6HRT5

  3. XM_039079527.2 → XP_038935455.1  zinc finger protein ZFAT isoform X3

    Conserved Domains (4) summary
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:270 → 292
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:284 → 308
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:298 → 322
    zf-H2C2_5; C2H2-type zinc-finger domain

RNA

  1. XR_005486668.2 RNA Sequence

  2. XR_005486669.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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