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CG8888 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36293, updated on 9-Dec-2024

Summary

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Official Symbol
CG8888provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033679
Locus tag
Dmel_CG8888
See related
AllianceGenome:FB:FBgn0033679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8888
Summary
Predicted to enable 3-hydroxybutyrate dehydrogenase activity. Predicted to be involved in steroid metabolic process. Located in plasma membrane. Is expressed in adult head; adult heart; larval muscle system; larval somatic muscle cell; and visceral mesoderm derivative. Used to study chromosome 3q29 microdeletion syndrome. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13. Orthologous to several human genes including BDH1 (3-hydroxybutyrate dehydrogenase 1); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and SDR9C7 (short chain dehydrogenase/reductase family 9C member 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG8888 in Genome Data Viewer
Location:
48D8-48E1; 2-66 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12064565..12079543, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7952070..7967048, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DNA fragmentation factor-related protein 3 Neighboring gene uncharacterized protein Neighboring gene jelly belly

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Quantitative Genomic Approach for Analysis of Fitness and Stress Related Traits in a Drosophila melanogaster Model Population. Duun Rohde P, et al. Int J Genomics, 2016. PMID 27274984, Free PMC Article
  2. LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila. Marcogliese PC, et al. Hum Mol Genet, 2017 Apr 1. PMID 28158614, Free PMC Article
  3. NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models. Singh MD, et al. PLoS Genet, 2020 Feb. PMID 32053595, Free PMC Article
  4. Drosophila, an emerging model for cardiac disease. Bier E, et al. Gene, 2004 Nov 10. PMID 15527959
  5. Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development. Yusuff T, et al. PLoS Genet, 2020 Jun. PMID 32579612, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3-hydroxybutyrate dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG8888-PA
NP_610724.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12064565..12079543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136880.3 → NP_610724.1  uncharacterized protein Dmel_CG8888 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610724.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3N4
    Related
    FBpp0087129
    Conserved Domains (2) summary
    pfam00106
    Location:96 → 293
    adh_short; short chain dehydrogenase
    cl21454
    Location:96 → 380
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3N4 Q7K3N4

Gene LinkOut

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