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Cep164 centrosomal protein 164 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363055, updated on 27-Nov-2024

Summary

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Official Symbol
Cep164provided by RGD
Official Full Name
centrosomal protein 164provided by RGD
Primary source
RGD:1561243
See related
EnsemblRapid:ENSRNOG00000029826 AllianceGenome:RGD:1561243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560988; RGD1561243
Summary
Predicted to be involved in cilium assembly. Predicted to be located in 9+2 motile cilium; apical part of cell; and nucleoplasm. Predicted to be part of ciliary transition fiber. Predicted to be active in centriole and centrosome. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and nephronophthisis 15. Orthologous to human CEP164 (centrosomal protein 164). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 94.4), Adrenal (RPKM 52.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cep164 in Genome Data Viewer
Location:
8q22
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54967621..55031264, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46070901..46134511, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50069282..50132477, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 2 Neighboring gene DS cell adhesion molecule-like 1 Neighboring gene beta-secretase 1 Neighboring gene ring finger protein 214 Neighboring gene proprotein convertase subtilisin/kexin type 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cep164, a novel centriole appendage protein required for primary cilium formation. Graser S, et al. J Cell Biol, 2007 Oct 22. PMID 17954613, Free PMC Article
  2. Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and the pronephros in zebrafish. Zhang Q, et al. Mol Biol Cell, 2012 Aug. PMID 22718903, Free PMC Article
  3. Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. Tomoda T, et al. J Gastroenterol Hepatol, 2012 Apr. PMID 22004425
  4. CCDC41 is required for ciliary vesicle docking to the mother centriole. Joo K, et al. Proc Natl Acad Sci U S A, 2013 Apr 9. PMID 23530209, Free PMC Article
  5. Centriole distal appendages promote membrane docking, leading to cilia initiation. Tanos BE, et al. Genes Dev, 2013 Jan 15. PMID 23348840, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in 9+2 motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of ciliary transition fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ciliary transition fiber ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 164 kDa
Names
centrosomal protein 164kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427257.1 → NP_001414186.1  centrosomal protein of 164 kDa

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    D3ZL75
    Related
    ENSRNOP00000022583.5, ENSRNOT00000022583.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    54967621..55031264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082355.2 → XP_038938283.1  centrosomal protein of 164 kDa isoform X5

    UniProtKB/TrEMBL
    A6J450
    Related
    ENSRNOP00000103121.1, ENSRNOT00000162398.1
    Conserved Domains (4) summary
    PHA03307
    Location:320 → 574
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:740 → 1086
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:924 → 1253
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam00397
    Location:58 → 87
    WW; WW domain

  2. XM_039082353.2 → XP_038938281.1  centrosomal protein of 164 kDa isoform X3

    UniProtKB/TrEMBL
    A0A8I6A687
    Related
    ENSRNOP00000086564.1, ENSRNOT00000113643.2
    Conserved Domains (2) summary
    COG1196
    Location:1243 → 1589
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00397
    Location:58 → 87
    WW; WW domain

  3. XM_039082354.2 → XP_038938282.1  centrosomal protein of 164 kDa isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:1122 → 1468
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:1306 → 1645
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam00397
    Location:58 → 87
    WW; WW domain

  4. XM_039082352.2 → XP_038938280.1  centrosomal protein of 164 kDa isoform X2

    Related
    ENSRNOP00000101338.1, ENSRNOT00000156361.1
    Conserved Domains (2) summary
    COG1196
    Location:1246 → 1592
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00397
    Location:58 → 87
    WW; WW domain

  5. XM_039082351.2 → XP_038938279.1  centrosomal protein of 164 kDa isoform X1

    UniProtKB/TrEMBL
    M0R9A9
    Related
    ENSRNOP00000066074.3, ENSRNOT00000072712.5
    Conserved Domains (2) summary
    COG1196
    Location:1295 → 1641
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00397
    Location:58 → 87
    WW; WW domain
Nucleotide Protein Strain
Heading Accession and Version

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