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EndoG Endonuclease G [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36309, updated on 18-Sep-2024

Summary

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Official Symbol
EndoGprovided by FlyBase
Official Full Name
Endonuclease Gprovided by FlyBase
Primary source
FLYBASE:FBgn0033690
Locus tag
Dmel_CG8862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8862; dEndoG; Dmel\CG8862; endoG; ENDOG
Orthologs
all
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Genomic context

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See EndoG in Genome Data Viewer
Location:
48E4-48E4; 2-66 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12177430..12178553, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8064935..8066058, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ornithine decarboxylase antizyme Neighboring gene antisense RNA:CR46194 Neighboring gene mir-281-2 stem loop Neighboring gene mir-281-1 stem loop Neighboring gene Chaperonin containing TCP1 subunit 5 Neighboring gene antisense RNA:CR45264 Neighboring gene uncharacterized protein Neighboring gene washout

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cellular inhibitor of apoptosis protein 1 ubiquitinates endonuclease G but does not affect endonuclease G-mediated cell death. Seo TW, et al. Biochem Biophys Res Commun, 2014 Sep 5. PMID 25139236
  2. The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G. Temme C, et al. J Biol Chem, 2009 Mar 27. PMID 19129189, Free PMC Article
  3. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article
  4. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208
  5. The Release 6 reference sequence of the Drosophila melanogaster genome. Hoskins RA, et al. Genome Res, 2015 Mar. PMID 25589440, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
endonuclease G
Names
CG8862-PA
EndoG-PA
NP_610737.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12177430..12178553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136893.4 → NP_610737.1  endonuclease G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610737.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JXB9
    Related
    FBpp0087120
    Conserved Domains (2) summary
    COG1864
    Location:39 → 305
    NUC1; DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]
    cd00091
    Location:77 → 309
    NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JXB9 Q7JXB9

Gene LinkOut

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