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Myzap myocardial zonula adherens protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 363091, updated on 9-Dec-2024

Summary

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Official Symbol
Myzapprovided by RGD
Official Full Name
myocardial zonula adherens proteinprovided by RGD
Primary source
RGD:1359197
See related
EnsemblRapid:ENSRNOG00000071258 AllianceGenome:RGD:1359197
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gcom1
Summary
Predicted to enable transcription elongation factor activity. Predicted to be involved in intracellular signal transduction. Located in cytoskeleton and membrane. Orthologous to several human genes including MYZAP (myocardial zonula adherens protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 1588.9), Lung (RPKM 415.1) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Myzap in Genome Data Viewer
Location:
8q24
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (81036599..81123933, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (72155817..72243036, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (78009019..78096409, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480072 Neighboring gene uncharacterized LOC120094203 Neighboring gene RNA polymerase II subunit M Neighboring gene dynein light chain LC8-type 1, pseudogene 1 Neighboring gene cingulin-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity. Roginski RS, et al. Neuroreport, 2008 Nov 19. PMID 18849881
  2. Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo. Seeger TS, et al. Circ Res, 2010 Mar 19. PMID 20093627, Free PMC Article
  3. Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy. Kluge A, et al. J Mol Cell Cardiol, 2019 Apr. PMID 30797814
  4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC109137

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in I band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in I band ISO
Inferred from Sequence Orthology
more info
  
located_in I band ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc IEA
Inferred from Electronic Annotation
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cortical actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myocardial zonula adherens protein
Names
GRINL1A combined protein
GRINL1A complex locus 1
GRINL1A complex locus protein 1
myozap

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014211.1 → NP_001014233.1  myocardial zonula adherens protein precursor

    See identical proteins and their annotated locations for NP_001014233.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089899
    UniProtKB/Swiss-Prot
    Q5EB94
    UniProtKB/TrEMBL
    A0A8I6AQM6, A6KER0
    Related
    ENSRNOP00000110374.1, ENSRNOT00000121939.1
    Conserved Domains (2) summary
    cd16269
    Location:277 → 290
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:205 → 310
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    81036599..81123933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081753.2 → XP_038937681.1  myocardial zonula adherens protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQM6
    Conserved Domains (1) summary
    COG1196
    Location:94 → 378
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_017595740.3 → XP_017451229.1  myocardial zonula adherens protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQM6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5EB94.1 GenPept UniProtKB/Swiss-Prot:Q5EB94

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials