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Esyt3 extended synaptotagmin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363120, updated on 27-Nov-2024

Summary

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Official Symbol
Esyt3provided by RGD
Official Full Name
extended synaptotagmin 3provided by RGD
Primary source
RGD:1561304
See related
EnsemblRapid:ENSRNOG00000022704 AllianceGenome:RGD:1561304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam62c; RGD1561304
Summary
Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in cytoplasmic side of plasma membrane and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ESYT3 (extended synaptotagmin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 28.0), Testes (RPKM 15.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Esyt3 in Genome Data Viewer
Location:
8q31
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (108749761..108796630, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (99870418..99917298, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107555417..107602414, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene Fas apoptotic inhibitory molecule like Neighboring gene centrosomal protein 70 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8, pseudogene 3 Neighboring gene uncharacterized LOC134480219 Neighboring gene muscle RAS oncogene homolog Neighboring gene NME/NM23 family member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains. Min SW, et al. Proc Natl Acad Sci U S A, 2007 Mar 6. PMID 17360437, Free PMC Article
  2. PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins. Giordano F, et al. Cell, 2013 Jun 20. PMID 23791178, Free PMC Article
  3. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Sandhu J, et al. Cell, 2018 Oct 4. PMID 30220461, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum-plasma membrane tethering IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-plasma membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
extended synaptotagmin-3
Names
extended synaptotagmin protein 3
extended synaptotagmin-like protein 3
family with sequence similarity 62 (C2 domain containing), member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429430.1 → NP_001416359.1  extended synaptotagmin-3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    D3ZC04

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    108749761..108796630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266441.1 → XP_063122511.1  extended synaptotagmin-3 isoform X3

    Related
    ENSRNOP00000108610.1, ENSRNOT00000142377.1

  2. XM_063266440.1 → XP_063122510.1  extended synaptotagmin-3 isoform X2

  3. XM_343454.9 → XP_343455.4  extended synaptotagmin-3 isoform X1

    Related
    ENSRNOP00000017658.6, ENSRNOT00000017658.9
    Conserved Domains (4) summary
    cd04030
    Location:758 → 883
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:448 → 571
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:310 → 428
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:118 → 294
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

  4. XM_063266442.1 → XP_063122512.1  extended synaptotagmin-3 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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